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Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.

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Title: Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.
Authors: Li JY; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China., Zhang XQ; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China., Sheng R; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China. sheng_rui@163.com.
Source: Journal of translational medicine [J Transl Med] 2026 Apr 21; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.
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  Data: <searchLink fieldCode="AU" term="%22Li+JY%22">Li JY</searchLink>; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XQ%22">Zhang XQ</searchLink>; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Sheng+R%22">Sheng R</searchLink>; Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China. sheng_rui@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Apr 21; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08044-x
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        Text: English
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              Text: 2026 Apr 21
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