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Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans.

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Title: Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans.
Authors: Schuster DJ; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA., Li SS; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Mielke D; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Seaton KE; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Brackett C; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Li K; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Shen X; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Wesley MS; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Eisel N; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Yates NL; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Zhang L; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Sawant S; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Stanfield-Oakley S; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Sholukh AM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Germain RS; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Li X; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hu J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Premkumar L; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA., Gallardo-Cartagena JA; Universidad Nacional Mayor de San Marcos, Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Lima, Peru., Randhawa AK; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Dennison SM; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Hural JA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Karuna S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ferrari G; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Hyrien O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Tomaras GD; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
Source: IScience [iScience] 2026 Mar 09; Vol. 29 (4), pp. 115277. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans.
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  Data: <searchLink fieldCode="AU" term="%22Schuster+DJ%22">Schuster DJ</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Li+SS%22">Li SS</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mielke+D%22">Mielke D</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Seaton+KE%22">Seaton KE</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Brackett+C%22">Brackett C</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wesley+MS%22">Wesley MS</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Eisel+N%22">Eisel N</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; 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Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stanfield-Oakley+S%22">Stanfield-Oakley S</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sholukh+AM%22">Sholukh AM</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Germain+RS%22">Germain RS</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Premkumar+L%22">Premkumar L</searchLink>; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gallardo-Cartagena+JA%22">Gallardo-Cartagena JA</searchLink>; Universidad Nacional Mayor de San Marcos, Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Randhawa+AK%22">Randhawa AK</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Dennison+SM%22">Dennison SM</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hural+JA%22">Hural JA</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Corey+L%22">Corey L</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Karuna+S%22">Karuna S</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22McElrath+MJ%22">McElrath MJ</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ferrari+G%22">Ferrari G</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hyrien+O%22">Hyrien O</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+GD%22">Tomaras GD</searchLink>; Center for Human Systems Immunology, Duke University School of Medicine, Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
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