View in EDS

Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial.

Saved in:
Bibliographic Details
Title: Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial.
Authors: Jacobs TG; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Pharmacy, Tergooi Medical Center, Hilversum, the Netherlands., Mumbiro V; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Tembo J; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia., Egbe FN; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK., Moraleda C; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain., Beca LSDAB; Department of Pharmacy, Lúrio University, Nampula, Mozambique., Passanduca A; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique., Kakooza L; Makerere University Lung Institute, Kampala, Uganda., Chitsamatanga M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Nduna B; Arthur Davidson Children's Hospital, Ndola, Zambia., Bramugy J; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique., Tagarro A; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Pediatric Service, Infanta Sofia University Hospital, Servicio Madrileño de Salud, Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain., Chhaganlal KD; Department of Research, Faculty of Health Sciences, Universidade Catolica de Mocambique, Beira, Mozambique., Mutesi S; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Mark NL; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Namuzizya N; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia., Ballesteros A; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain., Dominguez-Rodríguez S; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain., Colbers A; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands., Sacarlal J; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique., Nalwanga D; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chabala C; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.; School of Medicine, University of Zambia, Lusaka, Zambia., Madrid L; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Buck WC; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.; University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA., Musiime V; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.; Joint Clinical Research Centre, Kampala, Uganda., Bates M; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; School of Natural Sciences, University of Lincoln, Lincoln, United Kingdom., Rojo P; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain.; Complutense University of Madrid, Madrid, Spain., Burger DM; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.
Corporate Authors: EMPIRICAL Clinical Trial Group
Source: EClinicalMedicine [EClinicalMedicine] 2026 Apr 13; Vol. 94, pp. 103899. Date of Electronic Publication: 2026 Apr 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42016921
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Jacobs+TG%22">Jacobs TG</searchLink>; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Pharmacy, Tergooi Medical Center, Hilversum, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mumbiro+V%22">Mumbiro V</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Tembo+J%22">Tembo J</searchLink>; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Egbe+FN%22">Egbe FN</searchLink>; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Moraleda+C%22">Moraleda C</searchLink>; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Beca+LSDAB%22">Beca LSDAB</searchLink>; Department of Pharmacy, Lúrio University, Nampula, Mozambique.<br /><searchLink fieldCode="AU" term="%22Passanduca+A%22">Passanduca A</searchLink>; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Kakooza+L%22">Kakooza L</searchLink>; Makerere University Lung Institute, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Chitsamatanga+M%22">Chitsamatanga M</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Nduna+B%22">Nduna B</searchLink>; Arthur Davidson Children's Hospital, Ndola, Zambia.<br /><searchLink fieldCode="AU" term="%22Bramugy+J%22">Bramugy J</searchLink>; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Tagarro+A%22">Tagarro A</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Pediatric Service, Infanta Sofia University Hospital, Servicio Madrileño de Salud, Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Chhaganlal+KD%22">Chhaganlal KD</searchLink>; Department of Research, Faculty of Health Sciences, Universidade Catolica de Mocambique, Beira, Mozambique.<br /><searchLink fieldCode="AU" term="%22Mutesi+S%22">Mutesi S</searchLink>; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Mark+NL%22">Mark NL</searchLink>; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Bwakura-Dangarembizi+M%22">Bwakura-Dangarembizi M</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Namuzizya+N%22">Namuzizya N</searchLink>; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Ballesteros+A%22">Ballesteros A</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dominguez-Rodríguez+S%22">Dominguez-Rodríguez S</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Colbers+A%22">Colbers A</searchLink>; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sacarlal+J%22">Sacarlal J</searchLink>; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Nalwanga+D%22">Nalwanga D</searchLink>; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Mujuru+HA%22">Mujuru HA</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Chabala+C%22">Chabala C</searchLink>; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.; School of Medicine, University of Zambia, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Madrid+L%22">Madrid L</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; London School of Hygiene and Tropical Medicine, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Buck+WC%22">Buck WC</searchLink>; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.; University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Musiime+V%22">Musiime V</searchLink>; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.; Joint Clinical Research Centre, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Bates+M%22">Bates M</searchLink>; HerpeZ Infection Research and Training, University Teaching Hospital, Lusaka, Zambia.; School of Natural Sciences, University of Lincoln, Lincoln, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rojo+P%22">Rojo P</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)-Fundación Biomédica del Hospital Universitario 12 de Octubre (FIB-H12O) Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain.; Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Burger+DM%22">Burger DM</searchLink>; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22EMPIRICAL+Clinical+Trial+Group%22">EMPIRICAL Clinical Trial Group</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101733727%22">EClinicalMedicine</searchLink> [EClinicalMedicine] 2026 Apr 13; Vol. 94, pp. 103899. <i>Date of Electronic Publication: </i>2026 Apr 13 (<i>Print Publication: </i>2026).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22The+Lancet%22">The Lancet </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101733727 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-5370 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225895370%22">25895370 </searchLink><i>NLM ISO Abbreviation: </i>EClinicalMedicine <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42016921
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.eclinm.2026.103899
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 103899
    Titles:
      – TitleFull: Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jacobs TG
      – PersonEntity:
          Name:
            NameFull: Mumbiro V
      – PersonEntity:
          Name:
            NameFull: Tembo J
      – PersonEntity:
          Name:
            NameFull: Egbe FN
      – PersonEntity:
          Name:
            NameFull: Moraleda C
      – PersonEntity:
          Name:
            NameFull: Beca LSDAB
      – PersonEntity:
          Name:
            NameFull: Passanduca A
      – PersonEntity:
          Name:
            NameFull: Kakooza L
      – PersonEntity:
          Name:
            NameFull: Chitsamatanga M
      – PersonEntity:
          Name:
            NameFull: Nduna B
      – PersonEntity:
          Name:
            NameFull: Bramugy J
      – PersonEntity:
          Name:
            NameFull: Tagarro A
      – PersonEntity:
          Name:
            NameFull: Chhaganlal KD
      – PersonEntity:
          Name:
            NameFull: Mutesi S
      – PersonEntity:
          Name:
            NameFull: Mark NL
      – PersonEntity:
          Name:
            NameFull: Bwakura-Dangarembizi M
      – PersonEntity:
          Name:
            NameFull: Namuzizya N
      – PersonEntity:
          Name:
            NameFull: Ballesteros A
      – PersonEntity:
          Name:
            NameFull: Dominguez-Rodríguez S
      – PersonEntity:
          Name:
            NameFull: Colbers A
      – PersonEntity:
          Name:
            NameFull: Sacarlal J
      – PersonEntity:
          Name:
            NameFull: Nalwanga D
      – PersonEntity:
          Name:
            NameFull: Mujuru HA
      – PersonEntity:
          Name:
            NameFull: Chabala C
      – PersonEntity:
          Name:
            NameFull: Madrid L
      – PersonEntity:
          Name:
            NameFull: Buck WC
      – PersonEntity:
          Name:
            NameFull: Musiime V
      – PersonEntity:
          Name:
            NameFull: Bates M
      – PersonEntity:
          Name:
            NameFull: Rojo P
      – PersonEntity:
          Name:
            NameFull: Burger DM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 13
              M: 04
              Text: 2026 Apr 13
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2589-5370
          Numbering:
            – Type: volume
              Value: 94
          Titles:
            – TitleFull: EClinicalMedicine
              Type: main
ResultId 1