Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure.
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| Title: | Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure. |
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| Authors: | Wang M; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Dai L; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Li Z; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Luo L; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Liu X; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Zhang Y; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Zhong X; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Wang L; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Zhang Y; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Dong W; Division of Hepato-Pancreato-Biliary Surgery Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China., Yu D; Department of Cardiac Intensive Care Unit People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) Zhengzhou China., Wang H; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Biology, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China., Lai P; Department of Cardiology First Affiliated Hospital of Gannan Medical University, Gannan Medical University Ganzhou Jiangxi China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education Gannan Medical University Ganzhou Jiangxi China., Madhusudhan T; Center for Thrombosis and Hemostasis Johannes Gutenberg University Medical Center Mainz Germany., Zeng H; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China., Wang H; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.; Department of Cardiology Tongji Xianning Hosptial Xianning Hubei China. |
| Source: | Journal of the American Heart Association [J Am Heart Assoc] 2026 May 05; Vol. 15 (9), pp. e046276. Date of Electronic Publication: 2026 Apr 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42017318 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Dai+L%22">Dai L</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Luo+L%22">Luo L</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Zhong+X%22">Zhong X</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Division of Hepato-Pancreato-Biliary Surgery Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; Department of Cardiac Intensive Care Unit People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) Zhengzhou China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Biology, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China.<br /><searchLink fieldCode="AU" term="%22Lai+P%22">Lai P</searchLink>; Department of Cardiology First Affiliated Hospital of Gannan Medical University, Gannan Medical University Ganzhou Jiangxi China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education Gannan Medical University Ganzhou Jiangxi China.<br /><searchLink fieldCode="AU" term="%22Madhusudhan+T%22">Madhusudhan T</searchLink>; Center for Thrombosis and Hemostasis Johannes Gutenberg University Medical Center Mainz Germany.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Cardiology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy Wuhan Hubei China.; Department of Cardiology Tongji Xianning Hosptial Xianning Hubei China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101580524%22">Journal of the American Heart Association</searchLink> [J Am Heart Assoc] 2026 May 05; Vol. 15 (9), pp. e046276. <i>Date of Electronic Publication: </i>2026 Apr 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101580524 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2047-9980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220479980%22">20479980 </searchLink><i>NLM ISO Abbreviation: </i>J Am Heart Assoc <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42017318 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/JAHA.125.046276 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e046276 Titles: – TitleFull: Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang M – PersonEntity: Name: NameFull: Dai L – PersonEntity: Name: NameFull: Li Z – PersonEntity: Name: NameFull: Luo L – PersonEntity: Name: NameFull: Liu X – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Zhong X – PersonEntity: Name: NameFull: Wang L – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Dong W – PersonEntity: Name: NameFull: Yu D – PersonEntity: Name: NameFull: Wang H – PersonEntity: Name: NameFull: Lai P – PersonEntity: Name: NameFull: Madhusudhan T – PersonEntity: Name: NameFull: Zeng H – PersonEntity: Name: NameFull: Wang H IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 05 Text: 2026 May 05 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2047-9980 Numbering: – Type: volume Value: 15 – Type: issue Value: 9 Titles: – TitleFull: Journal of the American Heart Association Type: main |
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