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Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.

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Title: Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.
Authors: Sunderland N; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom., Asselin G; Montreal Heart Institute, Pharmacogenomics Centre, Montréal, Québec, Canada., Henry A; Institute of Cardiovascular Science, University College London, London, United Kingdom., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Lemieux Perreault LP; Montreal Heart Institute, Pharmacogenomics Centre, Montréal, Québec, Canada., Asselbergs FW; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; The National Institute for Health and Care Research University College London Biomedical Research Centre, University College London, London, United Kingdom; Institute of Health Informatics, University College London, London, United Kingdom., Boersma E; Department of Cardiology, Cardiovascular Institute, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chazara O; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Chutkow W; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Cyr MC; Montreal Heart Institute, Pharmacogenomics Centre, Montréal, Québec, Canada., Gkatzionis A; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA., Haefliger C; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Hedman ÅK; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Hillege H; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hyde CL; Pfizer Worldwide Research & Development, Cambridge, Massachusetts, USA., Kamanu FK; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Kardys I; Department of Cardiology, Cardiovascular Institute, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Koekemoer AL; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Kraus WE; Duke University School of Medicine, Durham, North Carolina, USA., Lang CC; Division of Cardiovascular Research, University of Dundee, Dundee, United Kingdom; Tuanku Muhriz Royal Chair, National University of Malaysia, Bangi, Malaysia., Malarstig A; Pfizer Worldwide Research & Development, Cambridge, Massachusetts, USA., Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Marston NA; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom., Melloni GEM; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Paul DS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Tilling K; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom., van der Harst P; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., van Setten J; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., van Vugt M; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Veluchamy A; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom., Wallentin L; Department Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden., Wang X; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Xing H; Sanofi Research, Cambridge, Massachusetts, USA., Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., White HD; Health New Zealand Te Whatu Ora, Te Toka Tumai Auckland, Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand., Zannad F; Universite de Lorraine, CHRU Nancy, Inserm, CIC, Nancy, France., Smith JG; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden; Science for Life Laboratory, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Brunner-La Rocca HP; Cardiovascular Research Institute (CARIM), Maastricht University, Maastricht, the Netherlands., Lanfear DE; Center for Individualized and Genomic Medicine Research, Henry Ford Health, Detroit, Michigan, USA., Mann DL; Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA., de Denus S; Montreal Heart Institute, and Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada., Tardif JC; Montreal Heart Institute, and Faculty of Medicine, Université de Montréal, Montrėal, Québec, Canada., Voors AA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Ellinor PT; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Cambridge, Massachusetts, USA., Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sattar N; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom., McMurray JJV; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom., Paternoster L; NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden., Dubé MP; Montreal Heart Institute, Pharmacogenomics Centre, and Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Lumbers RT; Institute of Health Informatics, University College London, London, United Kingdom. Electronic address: t.lumbers@ucl.ac.uk.
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Jun 02; Vol. 87 (21), pp. 2981-2992. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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Montreal Heart Institute, Pharmacogenomics Centre, and Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Lumbers+RT%22">Lumbers RT</searchLink>; Institute of Health Informatics, University College London, London, United Kingdom. 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            NameFull: Tardif JC
      – PersonEntity:
          Name:
            NameFull: Voors AA
      – PersonEntity:
          Name:
            NameFull: Samani NJ
      – PersonEntity:
          Name:
            NameFull: Ellinor PT
      – PersonEntity:
          Name:
            NameFull: Ruff CT
      – PersonEntity:
          Name:
            NameFull: Sabatine MS
      – PersonEntity:
          Name:
            NameFull: Sattar N
      – PersonEntity:
          Name:
            NameFull: McMurray JJV
      – PersonEntity:
          Name:
            NameFull: Paternoster L
      – PersonEntity:
          Name:
            NameFull: Dubé MP
      – PersonEntity:
          Name:
            NameFull: Lumbers RT
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 06
              Text: 2026 Jun 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1558-3597
          Numbering:
            – Type: volume
              Value: 87
            – Type: issue
              Value: 21
          Titles:
            – TitleFull: Journal of the American College of Cardiology
              Type: main
ResultId 1