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Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib.

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Title: Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib.
Authors: Thangavadivel S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Shaffer J; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Misra S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Benrashid S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Gordon BK; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., He A; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Li W; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Oyman K; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Chura A; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Cabrera S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Turkoglu A; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Lai TH; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Rogers KA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Bhat SA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Byrd JC; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Blachly JS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Woyach JA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Blaser BW; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 May 01; Vol. 32 (9), pp. 1874-1886.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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              Text: 2026 May 01
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