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Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles.

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Title: Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles.
Authors: Toesca J; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Castell M; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Jacquemin C; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Lalande A; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Laboratoire P4 INSERM-Jean Mérieux, Lyon, France., Ogire E; CIRI, Centre International de Recherche en Infectiologie, Team NeuroInvasion, Tropism and Viral Encephalitis, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Burlaud-Gaillard J; Inserm, U1259, Morphogénèse et Antigénicité du VIH, des Virus des Hépatites et émergents (MAVIVHe) & Inserm, Analyse des Systèmes Biologiques (ASB), Université de Tours et CHRU de Tours, Tours, France., Roingeard P; Inserm, U1259, Morphogénèse et Antigénicité du VIH, des Virus des Hépatites et émergents (MAVIVHe) & Inserm, Analyse des Systèmes Biologiques (ASB), Université de Tours et CHRU de Tours, Tours, France., Ramière C; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Virology Department, Institut des Agents Infectieux, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France., Mathieu C; CIRI, Centre International de Recherche en Infectiologie, Team NeuroInvasion, Tropism and Viral Encephalitis, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Perrin-Cocon L; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Lotteau V; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Laboratoire P4 INSERM-Jean Mérieux, Lyon, France., Vidalain PO; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France., Diaz O; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.
Source: PLoS pathogens [PLoS Pathog] 2026 Apr 22; Vol. 22 (4), pp. e1014165. Date of Electronic Publication: 2026 Apr 22 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles.
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  Data: <searchLink fieldCode="AU" term="%22Toesca+J%22">Toesca J</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Castell+M%22">Castell M</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Jacquemin+C%22">Jacquemin C</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lalande+A%22">Lalande A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Laboratoire P4 INSERM-Jean Mérieux, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ogire+E%22">Ogire E</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team NeuroInvasion, Tropism and Viral Encephalitis, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Burlaud-Gaillard+J%22">Burlaud-Gaillard J</searchLink>; Inserm, U1259, Morphogénèse et Antigénicité du VIH, des Virus des Hépatites et émergents (MAVIVHe) & Inserm, Analyse des Systèmes Biologiques (ASB), Université de Tours et CHRU de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Roingeard+P%22">Roingeard P</searchLink>; Inserm, U1259, Morphogénèse et Antigénicité du VIH, des Virus des Hépatites et émergents (MAVIVHe) & Inserm, Analyse des Systèmes Biologiques (ASB), Université de Tours et CHRU de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Ramière+C%22">Ramière C</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Virology Department, Institut des Agents Infectieux, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Mathieu+C%22">Mathieu C</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team NeuroInvasion, Tropism and Viral Encephalitis, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Perrin-Cocon+L%22">Perrin-Cocon L</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lotteau+V%22">Lotteau V</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Laboratoire P4 INSERM-Jean Mérieux, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Vidalain+PO%22">Vidalain PO</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Diaz+O%22">Diaz O</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Team Viral Infection, Metabolism and Immunity, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2026 Apr 22; Vol. 22 (4), pp. e1014165. <i>Date of Electronic Publication: </i>2026 Apr 22 (<i>Print Publication: </i>2026).
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