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Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression.

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Title: Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression.
Authors: Yang R; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Hu L; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.; Guangzhou National Laboratory, Guangzhou 510005, China., Wang J; State Key Laboratory of Membrane Biology, Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China., Wang J; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Yuan L; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Wu M; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., He L; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Yu W; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Chen P; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.; College of Chemistry and Materials Science, Langfang Normal University, Langfang 065000, China., Lu X; School of Engineering, Xi'an International University, Xi'an 710077, China.; School of Life Sciences, Westlake University, Hangzhou 310030, China., Hu F; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Zhang H; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Gao H; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Wang X; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China., Zhang H; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Sun Y; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Xu J; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Huang J; School of Life Sciences, Westlake University, Hangzhou 310030, China., Zhou H; Department of Analytical Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhu J; Etern Biopharma, Shanghai 201210, China., Wei F; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Jin Y; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Pudong New Area People's Hospital, Shanghai 201299, China., Gao Y; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Fu Q; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China., Qi X; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China., Yu J; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China., Li P; State Key Laboratory of Membrane Biology, Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China., He X; MOE Key Laboratory of Cell Proliferation and Regulation Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China., Zhang L; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Source: Science translational medicine [Sci Transl Med] 2026 Apr 22; Vol. 18 (846), pp. eadu0814. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression.
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  Data: <searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.; Guangzhou National Laboratory, Guangzhou 510005, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; State Key Laboratory of Membrane Biology, Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Yuan+L%22">Yuan L</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Yu+W%22">Yu W</searchLink>; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.; College of Chemistry and Materials Science, Langfang Normal University, Langfang 065000, China.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; School of Engineering, Xi'an International University, Xi'an 710077, China.; School of Life Sciences, Westlake University, Hangzhou 310030, China.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; School of Life Sciences, Westlake University, Hangzhou 310030, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Analytical Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Etern Biopharma, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Wei+F%22">Wei F</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Jin+Y%22">Jin Y</searchLink>; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Pudong New Area People's Hospital, Shanghai 201299, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.<br /><searchLink fieldCode="AU" term="%22Fu+Q%22">Fu Q</searchLink>; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.<br /><searchLink fieldCode="AU" term="%22Qi+X%22">Qi X</searchLink>; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; State Key Laboratory of Membrane Biology, Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; MOE Key Laboratory of Cell Proliferation and Regulation Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Urology, Shanghai Sixth People' s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China.; Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Apr 22; Vol. 18 (846), pp. eadu0814. <i>Date of Electronic Publication: </i>2026 Apr 22.
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