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KLK10 Upregulation Drives Aggressiveness and Radioresistance and Has a Negative Prognostic Impact on Rectal Cancer.

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Title: KLK10 Upregulation Drives Aggressiveness and Radioresistance and Has a Negative Prognostic Impact on Rectal Cancer.
Authors: Chou CL; Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan., Lin CW; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Li WS; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan., Lee SW; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Radiation Oncology, Chi Mei Medical Center, Liouying, Taiwan., Kuo YH; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan; College of Pharmacy and Science, Chia Nan University, Tainan, Taiwan., Shiue YL; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan., Li CF; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Trans-Omic Laboratory for Precision Medicine, Precision Medicine Center, Chi Mei Medical Center, Tainan, Taiwan., Lai HY; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Trans-Omic Laboratory for Precision Medicine, Precision Medicine Center, Chi Mei Medical Center, Tainan, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address: golddigger815@yahoo.com.tw., Yang CC; Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address: cleanclear0905@gmail.com.
Source: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2026 Jun; Vol. 106 (6), pp. 106128. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0376617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0307 (Electronic) Linking ISSN: 00236837 NLM ISO Abbreviation: Lab Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: KLK10 Upregulation Drives Aggressiveness and Radioresistance and Has a Negative Prognostic Impact on Rectal Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chou+CL%22">Chou CL</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CW%22">Lin CW</searchLink>; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+WS%22">Li WS</searchLink>; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+SW%22">Lee SW</searchLink>; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Radiation Oncology, Chi Mei Medical Center, Liouying, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+YH%22">Kuo YH</searchLink>; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan; College of Pharmacy and Science, Chia Nan University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shiue+YL%22">Shiue YL</searchLink>; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CF%22">Li CF</searchLink>; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Trans-Omic Laboratory for Precision Medicine, Precision Medicine Center, Chi Mei Medical Center, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+HY%22">Lai HY</searchLink>; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Trans-Omic Laboratory for Precision Medicine, Precision Medicine Center, Chi Mei Medical Center, Tainan, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address: golddigger815@yahoo.com.tw.<br /><searchLink fieldCode="AU" term="%22Yang+CC%22">Yang CC</searchLink>; Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address: cleanclear0905@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%220376617%22">Laboratory investigation; a journal of technical methods and pathology</searchLink> [Lab Invest] 2026 Jun; Vol. 106 (6), pp. 106128. <i>Date of Electronic Publication: </i>2026 Apr 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0376617 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1530-0307 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200236837%22">00236837 </searchLink><i>NLM ISO Abbreviation: </i>Lab Invest <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.labinv.2026.106128
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      – Code: eng
        Text: English
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        StartPage: 106128
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      – TitleFull: KLK10 Upregulation Drives Aggressiveness and Radioresistance and Has a Negative Prognostic Impact on Rectal Cancer.
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            NameFull: Chou CL
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            NameFull: Lin CW
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            NameFull: Li WS
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            NameFull: Shiue YL
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            NameFull: Li CF
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 1530-0307
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              Value: 106
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              Value: 6
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            – TitleFull: Laboratory investigation; a journal of technical methods and pathology
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