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Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism.

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Title: Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism.
Authors: Koochaki P; Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA., Qiu B; Department of Physiology & Biophysics, Weill Cornell Medicine, New York, NY, USA.; Howard Hughes Medical Institute, Weill Cornell Medicine, New York, NY, USA., Coker JA; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland, OH, USA.; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Case Western Reserve University, Cleveland, OH, USA., Earsley A; Department of Physiology & Biophysics, Weill Cornell Medicine, New York, NY, USA., Wang NS; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland, OH, USA., Romigh T; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland, OH, USA., Goins CM; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland, OH, USA.; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Case Western Reserve University, Cleveland, OH, USA., Salem C; Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA., Mi D; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Days E; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Bauer JA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Stauffer SR; Center for Therapeutics Discovery, Cleveland Clinic Research, Cleveland, OH, USA. stauffs2@ccf.org.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. stauffs2@ccf.org., Boudker O; Department of Physiology & Biophysics, Weill Cornell Medicine, New York, NY, USA. olb2003@med.cornell.edu.; Howard Hughes Medical Institute, Weill Cornell Medicine, New York, NY, USA. olb2003@med.cornell.edu., Chakraborty AA; Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA. chakraa@ccf.org.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. chakraa@ccf.org.; Case Comprehensive Cancer Center, Cleveland, OH, USA. chakraa@ccf.org.
Source: The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (11), pp. 3763-3787. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Jun
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