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Prothrombinase processivity is conferred by substrate allostery.

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Title: Prothrombinase processivity is conferred by substrate allostery.
Authors: Üstok FI; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom., Faille A; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.; Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, United Kingdom., Warren AJ; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.; Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, United Kingdom., Huntington JA; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom. jah52@cam.ac.uk.
Source: The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (11), pp. 3954-3977. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Üstok+FI%22">Üstok FI</searchLink>; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Faille+A%22">Faille A</searchLink>; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.; Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Warren+AJ%22">Warren AJ</searchLink>; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom.; Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huntington+JA%22">Huntington JA</searchLink>; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge, CB2 0XY, United Kingdom. jah52@cam.ac.uk.
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        Value: 10.1038/s44318-026-00782-4
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              Text: 2026 Jun
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