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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states.

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Title: Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states.
Authors: Calvo Fernández E; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Tomassoni L; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; DarwinHealth Inc., New York, NY, USA., Zhang X; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA., Wang J; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Ophthalmology and Stein Eye Institute, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA., Obradovic A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Laise P; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; DarwinHealth Inc., New York, NY, USA., Griffin AT; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA., Vlahos L; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Minns HE; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Oregon Health and Science University School of Medicine, Portland, OR, USA., Morales DV; Oncology Precision Therapeutics and Imaging Core, Columbia University Irving Medical Center, New York, NY, USA., Simmons C; Oncology Precision Therapeutics and Imaging Core, Columbia University Irving Medical Center, New York, NY, USA., Gallitto M; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA., Wei HJ; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, USA., Martins TJ; Quellos High Throughput Screening Core, University of Washington School of Medicine, Seattle, WA, USA., Becker PS; Departments of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Translational Science, City of Hope, Duarte, CA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Crawford JR; Department of Pediatrics, University of California Irvine, Irvine, CA, USA.; Department of Pediatrics, Children's Hospital Orange County, Orange, CA, USA., Tzaridis T; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Wechsler-Reya RJ; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Garvin J; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Gartrell RD; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Oncology, Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Szalontay L; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Zacharoulis S; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Wu CC; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA., Zhang Z; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Biohub New York, New York, NY, USA. ac2248@cumc.columbia.edu., Pavisic J; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Source: Nature genetics [Nat Genet] 2026 May; Vol. 58 (5), pp. 1112-1125. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states.
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  Data: <searchLink fieldCode="AU" term="%22Calvo+Fernández+E%22">Calvo Fernández E</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tomassoni+L%22">Tomassoni L</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; DarwinHealth Inc., New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Ophthalmology and Stein Eye Institute, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Obradovic+A%22">Obradovic A</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Laise+P%22">Laise P</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; DarwinHealth Inc., New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+AT%22">Griffin AT</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vlahos+L%22">Vlahos L</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Minns+HE%22">Minns HE</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Oregon Health and Science University School of Medicine, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Morales+DV%22">Morales DV</searchLink>; Oncology Precision Therapeutics and Imaging Core, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+C%22">Simmons C</searchLink>; Oncology Precision Therapeutics and Imaging Core, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gallitto+M%22">Gallitto M</searchLink>; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wei+HJ%22">Wei HJ</searchLink>; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.<br /><searchLink fieldCode="AU" term="%22Martins+TJ%22">Martins TJ</searchLink>; Quellos High Throughput Screening Core, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Becker+PS%22">Becker PS</searchLink>; Departments of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Translational Science, City of Hope, Duarte, CA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+JR%22">Crawford JR</searchLink>; Department of Pediatrics, University of California Irvine, Irvine, CA, USA.; Department of Pediatrics, Children's Hospital Orange County, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tzaridis+T%22">Tzaridis T</searchLink>; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wechsler-Reya+RJ%22">Wechsler-Reya RJ</searchLink>; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Garvin+J%22">Garvin J</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gartrell+RD%22">Gartrell RD</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Oncology, Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Szalontay+L%22">Szalontay L</searchLink>; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Zacharoulis+S%22">Zacharoulis S</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wu+CC%22">Wu CC</searchLink>; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.; Brain Tumor Institute, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Califano+A%22">Califano A</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA. ac2248@cumc.columbia.edu.; Biohub New York, New York, NY, USA. ac2248@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Pavisic+J%22">Pavisic J</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 May; Vol. 58 (5), pp. 1112-1125. <i>Date of Electronic Publication: </i>2026 Apr 22.
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