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Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin.

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Title: Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin.
Authors: Ren Z; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA., Chhetri A; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA., Liu C; Departments of Biological Sciences, Chemistry and Bioengineering, Lehigh University, Bethlehem, PA, USA., Offner S; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Sharma K; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Borgnia MJ; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Im W; Departments of Biological Sciences, Chemistry and Bioengineering, Lehigh University, Bethlehem, PA, USA., Yokoyama K; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA. ken.yoko@duke.edu.; Department of Chemistry, Duke University, Durham, NC, USA. ken.yoko@duke.edu., Lee SY; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA. seok-yong.lee@duke.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8118), pp. 547-555. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ren+Z%22">Ren Z</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chhetri+A%22">Chhetri A</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Departments of Biological Sciences, Chemistry and Bioengineering, Lehigh University, Bethlehem, PA, USA.<br /><searchLink fieldCode="AU" term="%22Offner+S%22">Offner S</searchLink>; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+K%22">Sharma K</searchLink>; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Borgnia+MJ%22">Borgnia MJ</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.; Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Im+W%22">Im W</searchLink>; Departments of Biological Sciences, Chemistry and Bioengineering, Lehigh University, Bethlehem, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yokoyama+K%22">Yokoyama K</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA. ken.yoko@duke.edu.; Department of Chemistry, Duke University, Durham, NC, USA. ken.yoko@duke.edu.<br /><searchLink fieldCode="AU" term="%22Lee+SY%22">Lee SY</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA. seok-yong.lee@duke.edu.
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              Text: 2026 Jun
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