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Dynamics of genetic and somatic trade-offs in ageing and mortality.

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Title: Dynamics of genetic and somatic trade-offs in ageing and mortality.
Authors: Arends D; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK. danny.arends@northumbria.ac.uk., Ashbrook DG; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK., Roy S; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Lu L; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Sloan Z; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Centeno AG; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Lamour KH; Department of Entomology and Plant Pathology, University of Tennessee Knoxville, Knoxville, TN, USA., de Magalhães JP; Department of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Prins P; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Broman KW; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Sen S; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., Mitchell SJ; Ludwig Princeton Branch, Princeton University, Princeton, NJ, USA., MacArthur MR; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Akin ÖA; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Li X; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Bajwa A; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA., Diaz V; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA., Harrison DE; The Jackson Laboratory, Bar Harbor, ME, USA., Strong R; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA., Nelson JF; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA., Mozhui K; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., Auwerx J; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Williams EG; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA., Williams RW; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA. rwilliams@uthsc.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8118), pp. 437-453. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Dynamics of genetic and somatic trade-offs in ageing and mortality.
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  Data: <searchLink fieldCode="AU" term="%22Arends+D%22">Arends D</searchLink>; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK. danny.arends@northumbria.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ashbrook+DG%22">Ashbrook DG</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Roy+S%22">Roy S</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sloan+Z%22">Sloan Z</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Centeno+AG%22">Centeno AG</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lamour+KH%22">Lamour KH</searchLink>; Department of Entomology and Plant Pathology, University of Tennessee Knoxville, Knoxville, TN, USA.<br /><searchLink fieldCode="AU" term="%22de+Magalhães+JP%22">de Magalhães JP</searchLink>; Department of Inflammation and Ageing, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Prins+P%22">Prins P</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Broman+KW%22">Broman KW</searchLink>; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Sen+S%22">Sen S</searchLink>; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+SJ%22">Mitchell SJ</searchLink>; Ludwig Princeton Branch, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22MacArthur+MR%22">MacArthur MR</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Akin+ÖA%22">Akin ÖA</searchLink>; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bajwa+A%22">Bajwa A</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Diaz+V%22">Diaz V</searchLink>; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+DE%22">Harrison DE</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Strong+R%22">Strong R</searchLink>; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+JF%22">Nelson JF</searchLink>; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mozhui+K%22">Mozhui K</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Auwerx+J%22">Auwerx J</searchLink>; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Williams+EG%22">Williams EG</searchLink>; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Miller+RA%22">Miller RA</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Williams+RW%22">Williams RW</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA. rwilliams@uthsc.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jun; Vol. 654 (8118), pp. 437-453. <i>Date of Electronic Publication: </i>2026 Apr 22.
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