Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.

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Title: Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.
Authors: Guerra P; Department of Medicine, University of Padova, Padova, Italy. pietro.guerra@phd.unipd.it., Villano G; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy., Rejano-Gordillo CM; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Gil-Pitarch C; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Ruvoletto M; Department of Medicine, University of Padova, Padova, Italy., Biasiolo A; Department of Medicine, University of Padova, Padova, Italy., Quarta S; Department of Medicine, University of Padova, Padova, Italy., Zapata-Pavas LE, Peña-SanFelix P; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., González-Recio I; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Goikoetxea-Usandizaga N; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Barrenechea-Barrenechea JA; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Sanz-Parra A; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Gambella A; Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy., De Siervi S; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Oliviero B; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Mantovani S; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Nurcis J; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Cagnin S; Department of Medicine, University of Padova, Padova, Italy., Martini A; Department of Medicine, Azienda Ospedale-Università of Padova, Padova, Italy., Turato C; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Cannito S; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Guido M; Department of Medicine, University of Padova, Padova, Italy., Parola M; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Martínez-Chantar ML; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain. mlmartinez@cicbiogune.es., Pontisso P; Department of Medicine, University of Padova, Padova, Italy.
Source: British journal of cancer [Br J Cancer] 2026 Jul; Vol. 135 (2), pp. 202-213. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-1827
DOI:10.1038/s41416-026-03427-9