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Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.

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Title: Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.
Authors: Guerra P; Department of Medicine, University of Padova, Padova, Italy. pietro.guerra@phd.unipd.it., Villano G; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy., Rejano-Gordillo CM; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Gil-Pitarch C; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Ruvoletto M; Department of Medicine, University of Padova, Padova, Italy., Biasiolo A; Department of Medicine, University of Padova, Padova, Italy., Quarta S; Department of Medicine, University of Padova, Padova, Italy., Zapata-Pavas LE, Peña-SanFelix P; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., González-Recio I; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Goikoetxea-Usandizaga N; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Barrenechea-Barrenechea JA; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Sanz-Parra A; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain., Gambella A; Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy., De Siervi S; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Oliviero B; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Mantovani S; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Nurcis J; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Cagnin S; Department of Medicine, University of Padova, Padova, Italy., Martini A; Department of Medicine, Azienda Ospedale-Università of Padova, Padova, Italy., Turato C; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Cannito S; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Guido M; Department of Medicine, University of Padova, Padova, Italy., Parola M; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Martínez-Chantar ML; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain. mlmartinez@cicbiogune.es., Pontisso P; Department of Medicine, University of Padova, Padova, Italy.
Source: British journal of cancer [Br J Cancer] 2026 Jul; Vol. 135 (2), pp. 202-213. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Guerra+P%22">Guerra P</searchLink>; Department of Medicine, University of Padova, Padova, Italy. pietro.guerra@phd.unipd.it.<br /><searchLink fieldCode="AU" term="%22Villano+G%22">Villano G</searchLink>; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Rejano-Gordillo+CM%22">Rejano-Gordillo CM</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Gil-Pitarch+C%22">Gil-Pitarch C</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Ruvoletto+M%22">Ruvoletto M</searchLink>; Department of Medicine, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Biasiolo+A%22">Biasiolo A</searchLink>; Department of Medicine, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Quarta+S%22">Quarta S</searchLink>; Department of Medicine, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Zapata-Pavas+LE%22">Zapata-Pavas LE</searchLink><br /><searchLink fieldCode="AU" term="%22Peña-SanFelix+P%22">Peña-SanFelix P</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22González-Recio+I%22">González-Recio I</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Goikoetxea-Usandizaga+N%22">Goikoetxea-Usandizaga N</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Barrenechea-Barrenechea+JA%22">Barrenechea-Barrenechea JA</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-Parra+A%22">Sanz-Parra A</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Gambella+A%22">Gambella A</searchLink>; Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22De+Siervi+S%22">De Siervi S</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Oliviero+B%22">Oliviero B</searchLink>; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Mantovani+S%22">Mantovani S</searchLink>; Department of Translational and Clinical Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Nurcis+J%22">Nurcis J</searchLink>; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Cagnin+S%22">Cagnin S</searchLink>; Department of Medicine, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Martini+A%22">Martini A</searchLink>; Department of Medicine, Azienda Ospedale-Università of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Turato+C%22">Turato C</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cannito+S%22">Cannito S</searchLink>; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Guido+M%22">Guido M</searchLink>; Department of Medicine, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Parola+M%22">Parola M</searchLink>; Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Martínez-Chantar+ML%22">Martínez-Chantar ML</searchLink>; Liver Disease and Liver Metabolism Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain. mlmartinez@cicbiogune.es.<br /><searchLink fieldCode="AU" term="%22Pontisso+P%22">Pontisso P</searchLink>; Department of Medicine, University of Padova, Padova, Italy.
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  Data: <searchLink fieldCode="JN" term="%220370635%22">British journal of cancer</searchLink> [Br J Cancer] 2026 Jul; Vol. 135 (2), pp. 202-213. <i>Date of Electronic Publication: </i>2026 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+on+behalf+of+Cancer+Research+UK%22">Nature Publishing Group on behalf of Cancer Research UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0370635 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1827 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070920%22">00070920 </searchLink><i>NLM ISO Abbreviation: </i>Br J Cancer <i>Subsets: </i>MEDLINE
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