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The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases.

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Title: The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases.
Authors: Zhang X; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), Institute of Brain Functional Genomics, School of Life Sciences and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, 200062, China., Zhang J; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Zhang Y; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Wang D; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China., Liu G; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China., Wang M; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China., Li C; Cancer Research Institute, School of Basic Medical Sciences, University of South China, Hengyang, 421001, China., Shi Q; National key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China., Dong X; National key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China., Yuan C; Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), Institute of Brain Functional Genomics, School of Life Sciences and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, 200062, China., Li W; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China., Ma J; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China. majiyan@cibr.ac.cn.; Chinese Institute for Brain Research, Beijing, 102206, China. majiyan@cibr.ac.cn.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Apr 22; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), Institute of Brain Functional Genomics, School of Life Sciences and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, 200062, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.; College of Biological Sciences, China Agricultural University, Beijing, 100193, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Cancer Research Institute, School of Basic Medical Sciences, University of South China, Hengyang, 421001, China.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; National key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; National key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Yuan+C%22">Yuan C</searchLink>; Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), Institute of Brain Functional Genomics, School of Life Sciences and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, 200062, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.; Chinese Institute for Brain Research, Beijing, 102206, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China. majiyan@cibr.ac.cn.; Chinese Institute for Brain Research, Beijing, 102206, China. majiyan@cibr.ac.cn.
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              Text: 2026 Apr 22
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