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Modic Change Bone Marrow Neutrophils Are Activated and Degrade Cartilage Endplates.

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Title: Modic Change Bone Marrow Neutrophils Are Activated and Degrade Cartilage Endplates.
Authors: Heggli I; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.; Department of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA., Mengis T; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland., Devan J; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland., Herger N; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland., Farshad M; Department of Orthopedics Balgrist University Hospital, University of Zurich Zurich Switzerland., Habib M; Department of Orthopaedic Surgery University of California San Francisco San Francisco California USA., Ames CP; Department of Neurological Surgery University of California San Francisco San Francisco California USA., Distler O; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland., Fields AJ; Department of Orthopaedic Surgery University of California San Francisco San Francisco California USA., Dudli S; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.
Source: JOR spine [JOR Spine] 2026 Mar 18; Vol. 9 (1), pp. e70170. Date of Electronic Publication: 2026 Mar 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Periodicals, Inc Country of Publication: United States NLM ID: 101722350 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-1143 (Electronic) Linking ISSN: 25721143 NLM ISO Abbreviation: JOR Spine Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Modic Change Bone Marrow Neutrophils Are Activated and Degrade Cartilage Endplates.
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  Data: <searchLink fieldCode="AU" term="%22Heggli+I%22">Heggli I</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.; Department of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.<br /><searchLink fieldCode="AU" term="%22Mengis+T%22">Mengis T</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Devan+J%22">Devan J</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Herger+N%22">Herger N</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Farshad+M%22">Farshad M</searchLink>; Department of Orthopedics Balgrist University Hospital, University of Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Habib+M%22">Habib M</searchLink>; Department of Orthopaedic Surgery University of California San Francisco San Francisco California USA.<br /><searchLink fieldCode="AU" term="%22Ames+CP%22">Ames CP</searchLink>; Department of Neurological Surgery University of California San Francisco San Francisco California USA.<br /><searchLink fieldCode="AU" term="%22Distler+O%22">Distler O</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Fields+AJ%22">Fields AJ</searchLink>; Department of Orthopaedic Surgery University of California San Francisco San Francisco California USA.<br /><searchLink fieldCode="AU" term="%22Dudli+S%22">Dudli S</searchLink>; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101722350%22">JOR spine</searchLink> [JOR Spine] 2026 Mar 18; Vol. 9 (1), pp. e70170. <i>Date of Electronic Publication: </i>2026 Mar 18 (<i>Print Publication: </i>2026).
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              Text: 2026 Mar 18
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