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Sex differences in levodopa pharmacokinetics in early Parkinson's disease: implications on levodopa-related complications.

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Title: Sex differences in levodopa pharmacokinetics in early Parkinson's disease: implications on levodopa-related complications.
Authors: Conti V; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., De Bellis E; PhD School 'Clinical and Translational Oncology (CTO)', Scuola Superiore Meridionale, University of Naples 'Federico II', Naples, Italy., Corbi G; Department of Translational Medical Sciences, University of Naples 'Federico II', Naples, Italy., Charlier B; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.; Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, Baronissi (SA), Italy., Izzo V; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., Russillo MC; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy., Amboni M; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., Picillo M; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., Scaglione CLM; IRCCS 'Istituto delle Scienze Neurologiche di Bologna', UOC Neurological Clinic, Bellaria Hospital, Bologna, Italy., Cani I; IRCCS 'Istituto delle Scienze Neurologiche di Bologna', UOC Neurological Clinic, Bellaria Hospital, Bologna, Italy., Cicero CE; Neurologic Unit, AOU 'Policlinico-San Marco', Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy., Nicoletti A; Neurologic Unit, AOU 'Policlinico-San Marco', Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy., Soricelli A; IRCCS SYNLAB SDN, Naples, Italy., Barone P; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., Filippelli A; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy., Pellecchia MT; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 07; Vol. 17, pp. 1748932. Date of Electronic Publication: 2026 Apr 07 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Sex differences in levodopa pharmacokinetics in early Parkinson's disease: implications on levodopa-related complications.
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  Data: <searchLink fieldCode="AU" term="%22Conti+V%22">Conti V</searchLink>; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22De+Bellis+E%22">De Bellis E</searchLink>; PhD School 'Clinical and Translational Oncology (CTO)', Scuola Superiore Meridionale, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Corbi+G%22">Corbi G</searchLink>; Department of Translational Medical Sciences, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Charlier+B%22">Charlier B</searchLink>; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.; Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, Baronissi (SA), Italy.<br /><searchLink fieldCode="AU" term="%22Izzo+V%22">Izzo V</searchLink>; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Russillo+MC%22">Russillo MC</searchLink>; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.<br /><searchLink fieldCode="AU" term="%22Amboni+M%22">Amboni M</searchLink>; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Picillo+M%22">Picillo M</searchLink>; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Scaglione+CLM%22">Scaglione CLM</searchLink>; IRCCS 'Istituto delle Scienze Neurologiche di Bologna', UOC Neurological Clinic, Bellaria Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cani+I%22">Cani I</searchLink>; IRCCS 'Istituto delle Scienze Neurologiche di Bologna', UOC Neurological Clinic, Bellaria Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cicero+CE%22">Cicero CE</searchLink>; Neurologic Unit, AOU 'Policlinico-San Marco', Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Nicoletti+A%22">Nicoletti A</searchLink>; Neurologic Unit, AOU 'Policlinico-San Marco', Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Soricelli+A%22">Soricelli A</searchLink>; IRCCS SYNLAB SDN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Barone+P%22">Barone P</searchLink>; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Filippelli+A%22">Filippelli A</searchLink>; Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.; Clinical Pharmacology Unit, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Pellecchia+MT%22">Pellecchia MT</searchLink>; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.; Neurological Clinic, San Giovanni di Dio e Ruggi d'Aragona University Hospital, Salerno, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Apr 07; Vol. 17, pp. 1748932. <i>Date of Electronic Publication: </i>2026 Apr 07 (<i>Print Publication: </i>2026).
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