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Functional analyses identify the L1 ORF2p Cryptic domain as a hub for intramolecular interfaces required for retrotransposition.

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Title: Functional analyses identify the L1 ORF2p Cryptic domain as a hub for intramolecular interfaces required for retrotransposition.
Authors: Shareef AM; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States., Chen G; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States., Christian CM; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States., Freeman B; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States., LaCoste D; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States., Gao S; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States., Africano Camargo E; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States., Ubi JN; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States., Belancio VP; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.; Research Geneticist, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70112, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 23; Vol. 54 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional analyses identify the L1 ORF2p Cryptic domain as a hub for intramolecular interfaces required for retrotransposition.
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  Data: <searchLink fieldCode="AU" term="%22Shareef+AM%22">Shareef AM</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.<br /><searchLink fieldCode="AU" term="%22Christian+CM%22">Christian CM</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.<br /><searchLink fieldCode="AU" term="%22Freeman+B%22">Freeman B</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.<br /><searchLink fieldCode="AU" term="%22LaCoste+D%22">LaCoste D</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.<br /><searchLink fieldCode="AU" term="%22Gao+S%22">Gao S</searchLink>; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States.<br /><searchLink fieldCode="AU" term="%22Africano+Camargo+E%22">Africano Camargo E</searchLink>; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States.<br /><searchLink fieldCode="AU" term="%22Ubi+JN%22">Ubi JN</searchLink>; Department of Chemical and Biomolecular Engineering, School of Science and Engineering, Tulane University, New Orleans, LA 70118, United States.<br /><searchLink fieldCode="AU" term="%22Belancio+VP%22">Belancio VP</searchLink>; Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Tulane Center for Aging, New Orleans, LA 70130, United States.; Research Geneticist, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70112, United States.
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        Value: 10.1093/nar/gkag317
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              Text: 2026 Apr 23
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