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The effect of clavulanic acid on the development of tolerance and dependence induced by morphine in mice: role of DRD2 and NR1 genes, oxidative stress, and GDNF protein.

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Title: The effect of clavulanic acid on the development of tolerance and dependence induced by morphine in mice: role of DRD2 and NR1 genes, oxidative stress, and GDNF protein.
Authors: Esmaili-Shahzade-Ali-Akbari P; Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Alani B; Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.; Department of Applied Cell Sciences, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Hosseini ES; Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran., Banafshe HR; Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran., Ardjmand A; Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.; Department of Physiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Nooshabadi MR; Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Haghparast A; Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghaderi A; Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran. gaderiam@gmail.com.; Clinical Research Development Unit-Matini/Kargarnejad Hospital, Kashan University of Medical Sciences, Kashan, Iran. gaderiam@gmail.com.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul; Vol. 399 (10), pp. 15241-15254. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Jul
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