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Effect Modification Analyses in Individual Participant Data Meta-Analyses: A Systematic Review.

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Title: Effect Modification Analyses in Individual Participant Data Meta-Analyses: A Systematic Review.
Authors: Gao Y; Department of Medical Dataology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.; National Institute of Health and Medical Big Data, Jinan, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China., Li Z; Department of Radiology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Liu M; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Zhao Y; Department of Geriatric Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Municipality Clinical Research Center for Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Asadollahifar A; Department of Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Yang K; Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven-University of Leuven, Leuven, Belgium., Shi S; Department of Medical Imaging, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Daneshmand M; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Xu J; Population Health Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada.; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China., Yao L; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Yang F; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.; Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Xue F; Department of Medical Dataology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.; National Institute of Health and Medical Big Data, Jinan, China.; Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Tian J; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.; Key Laboratory of Evidence-Based Medicine of Gansu Province, Lanzhou, China., Zhang J; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.; Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Guyatt G; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; MAGIC Evidence Ecosystem Foundation, Oslo, Norway.
Source: JAMA network open [JAMA Netw Open] 2026 Apr 01; Vol. 9 (4), pp. e268810. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect Modification Analyses in Individual Participant Data Meta-Analyses: A Systematic Review.
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  Data: <searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Medical Dataology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.; National Institute of Health and Medical Big Data, Jinan, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Radiology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Geriatric Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Municipality Clinical Research Center for Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Asadollahifar+A%22">Asadollahifar A</searchLink>; Department of Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven-University of Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Shi+S%22">Shi S</searchLink>; Department of Medical Imaging, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Daneshmand+M%22">Daneshmand M</searchLink>; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada.; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Yao+L%22">Yao L</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.; Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Xue+F%22">Xue F</searchLink>; Department of Medical Dataology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.; National Institute of Health and Medical Big Data, Jinan, China.; Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Tian+J%22">Tian J</searchLink>; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.; Key Laboratory of Evidence-Based Medicine of Gansu Province, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.; Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Guyatt+G%22">Guyatt G</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; MAGIC Evidence Ecosystem Foundation, Oslo, Norway.
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              Text: 2026 Apr 01
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