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Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.

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Title: Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.
Authors: Cruz ACL; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: acdermatologiaclinica@gmail.com., Cassiano DP; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Miot HA; Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil., Espósito ACC; Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil; Service of Dermatology, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil., Hassum K; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., de Brito MB; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., E Silva Enokihara MMS; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Lima Constantino MCC; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Bottura HR; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., de Almeida JS; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Bagatin E; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Source: Anais brasileiros de dermatologia [An Bras Dermatol] 2026 May-Jun; Vol. 101 (3), pp. 501336. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier España, S.L Country of Publication: Spain NLM ID: 0067662 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-4841 (Electronic) Linking ISSN: 03650596 NLM ISO Abbreviation: An Bras Dermatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.
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  Data: <searchLink fieldCode="AU" term="%22Cruz+ACL%22">Cruz ACL</searchLink>; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: acdermatologiaclinica@gmail.com.<br /><searchLink fieldCode="AU" term="%22Cassiano+DP%22">Cassiano DP</searchLink>; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Miot+HA%22">Miot HA</searchLink>; Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Espósito+ACC%22">Espósito ACC</searchLink>; Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil; Service of Dermatology, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Hassum+K%22">Hassum K</searchLink>; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Brito+MB%22">de Brito MB</searchLink>; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22E+Silva+Enokihara+MMS%22">E Silva Enokihara MMS</searchLink>; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Lima+Constantino+MCC%22">Lima Constantino MCC</searchLink>; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bottura+HR%22">Bottura HR</searchLink>; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+JS%22">de Almeida JS</searchLink>; Department of Histopathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bagatin+E%22">Bagatin E</searchLink>; Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
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  Data: <searchLink fieldCode="JN" term="%220067662%22">Anais brasileiros de dermatologia</searchLink> [An Bras Dermatol] 2026 May-Jun; Vol. 101 (3), pp. 501336. <i>Date of Electronic Publication: </i>2026 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+España%2C+S%2EL%22">Elsevier España, S.L </searchLink><i>Country of Publication: </i>Spain <i>NLM ID: </i>0067662 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1806-4841 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203650596%22">03650596 </searchLink><i>NLM ISO Abbreviation: </i>An Bras Dermatol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.abd.2026.501336
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              M: 05
              Text: 2026 May-Jun
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