Empirical evaluation of analytic validity of polygenic scores.

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Title: Empirical evaluation of analytic validity of polygenic scores.
Authors: Lin T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Zeng J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Gordon SD; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Wallace L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Ziser L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Pain O; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., James PA; Peter MacCallum Cancer Centre, Melbourne, Australia., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lee E; Preciselee, Sydney, NSW, 2065, Australia., Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. Naomi.wray@psych.ox.ac.uk.; Department of Psychiatry, University of Oxford, Oxford, UK. Naomi.wray@psych.ox.ac.uk.
Corporate Authors: Lifelines Cohort Study
Source: Genome medicine [Genome Med] 2026 Apr 23; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lin+T%22">Lin T</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Gordon+SD%22">Gordon SD</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Wallace+L%22">Wallace L</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Ziser+L%22">Ziser L</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Pain+O%22">Pain O</searchLink>; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nolte+IM%22">Nolte IM</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Snieder+H%22">Snieder H</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22James+PA%22">James PA</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+NG%22">Martin NG</searchLink>; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Visscher+PM%22">Visscher PM</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Preciselee, Sydney, NSW, 2065, Australia.<br /><searchLink fieldCode="AU" term="%22Yengo+L%22">Yengo L</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Henders+AK%22">Henders AK</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Wray+NR%22">Wray NR</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. Naomi.wray@psych.ox.ac.uk.; Department of Psychiatry, University of Oxford, Oxford, UK. Naomi.wray@psych.ox.ac.uk.
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