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Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion.

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Title: Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion.
Authors: Guo C; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Cavalcante F; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Yang S; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Suzuki K; Department of Neurology, Nippon Medical School, Tokyo, Japan., Treurniet K; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology, Haaglanden Medical Centre, The Hague, The Netherlands., Kaesmacher J; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland.; Diagnostic and Interventional Neuroradiology, CIC-IT 1415, CHRU de Tours, Tours, France.; Le Studium Loire Valley Institute for Advanced Studies, Tours, France., Kappelhof M; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology, Onze Lieve Vrouwe Gasthuis (OLVG) Hospital, Amsterdam, The Netherlands., Rohner R; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland., Song J; The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China., Yang P; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.; Oriental PanVascular Devices Innovations College, University of Shanghai for Science and Technology, Shanghai, People's Republic of China., Shi X; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Li G; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Xu X; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Ma J; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Wang L; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Liu J; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.; Oriental PanVascular Devices Innovations College, University of Shanghai for Science and Technology, Shanghai, People's Republic of China., Li L; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Xing P; Department of Radiology, Onze Lieve Vrouwe Gasthuis (OLVG) Hospital, Amsterdam, The Netherlands.; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China., Yan B; Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Liu C; The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China., Zhang L; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China., Zhang Y; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China., Redmond K; Interventional Neuroradiology, Gold Coast University Hospital, Southport, Queensland, Australia., Zhou Y; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China., Mitchell P; Interventional Neuroradiology, Gold Coast University Hospital, Southport, Queensland, Australia., Heldner MR; Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Lingsma H; Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands., Gralla J; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland., Fischer U; Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Bern, Switzerland., Roos Y; Department of Neurology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Li F; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Nogueira RG; UPMC Stroke Institute, Departments of Neurology and Neurosurgery, University of Pittsburgh Medical Centre, Pittsburgh, PA., Nguyen T; Department of Neurology, Neurosurgery, and Radiology, Boston Medical Centre, Boston, MA., Saver J; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA., Majoie C; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Kimura K; Department of Neurology, Nippon Medical School, Tokyo, Japan., Zi W; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China., Yang Q; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.
Corporate Authors: IRIS Investigators
Source: Annals of neurology [Ann Neurol] 2026 Jul; Vol. 100 (1), pp. 180-190. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: <searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Cavalcante+F%22">Cavalcante F</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Department of Neurology, Nippon Medical School, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Treurniet+K%22">Treurniet K</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology, Haaglanden Medical Centre, The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kaesmacher+J%22">Kaesmacher J</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland.; Diagnostic and Interventional Neuroradiology, CIC-IT 1415, CHRU de Tours, Tours, France.; Le Studium Loire Valley Institute for Advanced Studies, Tours, France.<br /><searchLink fieldCode="AU" term="%22Kappelhof+M%22">Kappelhof M</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology, Onze Lieve Vrouwe Gasthuis (OLVG) Hospital, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rohner+R%22">Rohner R</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.; Oriental PanVascular Devices Innovations College, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.; Oriental PanVascular Devices Innovations College, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xing+P%22">Xing P</searchLink>; Department of Radiology, Onze Lieve Vrouwe Gasthuis (OLVG) Hospital, Amsterdam, The Netherlands.; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yan+B%22">Yan B</searchLink>; Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Redmond+K%22">Redmond K</searchLink>; Interventional Neuroradiology, Gold Coast University Hospital, Southport, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Neurovascular Centre, Naval Medical University Changhai Hospital, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Mitchell+P%22">Mitchell P</searchLink>; Interventional Neuroradiology, Gold Coast University Hospital, Southport, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Heldner+MR%22">Heldner MR</searchLink>; Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lingsma+H%22">Lingsma H</searchLink>; Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gralla+J%22">Gralla J</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fischer+U%22">Fischer U</searchLink>; Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roos+Y%22">Roos Y</searchLink>; Department of Neurology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Nogueira+RG%22">Nogueira RG</searchLink>; UPMC Stroke Institute, Departments of Neurology and Neurosurgery, University of Pittsburgh Medical Centre, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Department of Neurology, Neurosurgery, and Radiology, Boston Medical Centre, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Saver+J%22">Saver J</searchLink>; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Majoie+C%22">Majoie C</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kimura+K%22">Kimura K</searchLink>; 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