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Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock.

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Title: Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock.
Authors: Balamuth F; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia., Weiss SL; Division of Critical Care, Department of Pediatrics, Nemours Children's Hospital, Wilmington, DE.; Departments of Pediatrics and Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia., Long E; Emergency Department, Royal Children's Hospital, Parkville, VIC, Australia.; Departments of Paediatrics and Critical Care, University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia., Thompson GC; Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada., Artis AS; Department of Biomedical and Health Informatics, Data Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia., Campos AB; Department of Biomedical and Health Informatics, Clinical Reporting Unit, Children's Hospital of Philadelphia, Philadelphia., Borland ML; Department of Emergency Medicine, Perth Children's Hospital, Nedlands, WA, Australia.; School of Medicine, University of Western Australia, Perth, Australia., Dalziel SR; Departments of Surgery and Pediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand., Yock-Corrales A; Department of Emergency Medicine, Hospital Nacional de Niños Dr. Carlos Sáenz Herrera, Caja Costarricense del Seguro Social, San José, Costa Rica., Singh R; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Williams A; Murdoch Children's Research Institute, Parkville, VIC, Australia., Mickiewicz B; Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada., Hickey CP; Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia.; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Fitzgerald JC; Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia.; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Laskin BL; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Hickey RW; Division of Pediatric Emergency Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh., Eckerle M; Department of Pediatrics, University of Cincinnati College of Medicine and Division of Emergency Medicine, Cincinnati Children's Hospital, Cincinnati., Alqurashi W; Children's Hospital of Eastern Ontario, Ottawa.; Departments of Pediatrics and Emergency Medicine, Faculty of Medicine, University of Ottawa, Children's Hospital of Eastern Ontario Research Institute, Ottawa., Alpern E; Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago., Ambroggio L; Section of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado and the Department of Pediatrics, University of Colorado Anschutz School of Medicine, Aurora., Badawy M; Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas., Baumer-Mouradian S; Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee., Berthelot S; Département de Médecine de Famille et de Médecine d'Urgence, Faculté de Médecine, Université Laval et Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec-Université Laval, Quebec, QC, Canada., Clukies LD; Division of Emergency Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis., Craig S; Paediatric Emergency Department, Monash Medical Centre, Melbourne, VIC, Australia.; Department of Pediatrics, Sub-Faculty of Clinical and Molecular Medicine, Monash University, Melbourne, VIC, Australia., Curtis SJ; Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alberta Stollery Children's Hospital, Edmonton, Canada.; Women and Children's Health Research Institute, Edmonton, AB, Canada., Davis AL; Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and the Department of Paediatrics, University of Toronto, Toronto., Duffy S; Hasbro Children's Hospital, Brown University Health, Providence, RI., Eisenberg MA; Division of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, Boston.; Departments of Pediatrics and Emergency Medicine, Harvard Medical School, Boston., Emsley JG; IWK Health Centre and Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Faculty of Medicine, Dalhousie University, Halifax NS, Canada., Festekjian A; Division of Emergency and Transport Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles.; Keck School of Medicine, University of Southern California, Los Angeles., George S; Department of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, QLD, Australia.; School of Medicine and Dentistry, Griffith University, Southport, QLD, Australia., Green R; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Gripp KE; Section of Pediatric Emergency Medicine, Department of Pediatrics and Child Health, Health Sciences Center Winnipeg Children's Hospital, Winnipeg, MB, Canada.; Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Jain PG; Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago., Jani S; Department of Emergency Medicine, Children's Hospital at Westmead, Westmead, NSW, Australia., Joubert GI; London Health Sciences Centre and Division of Emergency Medicine, Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada., Judge P; British Columbia Children's Hospital, Department of Pediatrics, Division of Pediatric Emergency Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Kam A; McMaster Children's Hospital and Division of Emergency Medicine, Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Kochar A; Department of Emergency Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.; Department of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia., Koutroulis I; Division of Emergency Medicine, Department of Pediatrics, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC., Kwok MY; Department of Emergency Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York., Lane RD; Division of Pediatric Emergency Medicine, Primary Children's Hospital, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City., Lithgow A; Department of Paediatrics, Royal Darwin Hospital, Tiwi, NT, Australia., Lloyd J; Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus., Mansour K; Division of Pediatric Emergency Medicine, Department of Emergency Medicine, University of California San Francisco Benioff Children's Hospitals, Oakland., McManemy JK; Division of Emergency Medicine, Department of Pediatrics, Texas Children's Hospital and the Department of Pediatrics, Baylor College of Medicine, Houston., Morris C; Division of Pediatric Emergency Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta., Phillips N; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia.; Child Health Research Centre, University of Queensland, Brisbane, Australia., Rao A; Department of Emergency Medicine, Sydney Children's Hospital, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Kensington, Australia., Rogers A; Departments of Emergency Medicine and Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor., Sehgal A; Kingston Health Sciences Centre and Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada., Shayan Y; Centre Hospitalier Universitaire Sainte Justine et Département de Pédiatrie, Université de Montréal, Montreal., Silverman J; Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Division of Critical Care, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond., Tan E; Middlemore Hospital, Auckland, New Zealand.; Department of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand., Uspal NG; University of Washington, Pediatric Emergency Medicine, Seattle Children's Hospital, Seattle., Vance C; University of California at Davis Children's Hospital and School of Medicine, Sacramento., Whyte E; Emergency Department, Townsville University Hospital, Douglas, QLD, Australia.; College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia., Huang J; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Freedman SB; Sections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics and Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Babl FE; Emergency Department, Royal Children's Hospital, Parkville, VIC, Australia.; Departments of Paediatrics and Critical Care, University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia., Kuppermann N; Division of Emergency Medicine, Department of Pediatrics, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC.
Corporate Authors: PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks
Source: The New England journal of medicine [N Engl J Med] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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  Data: Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock.
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Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago.<br /><searchLink fieldCode="AU" term="%22Ambroggio+L%22">Ambroggio L</searchLink>; Section of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado and the Department of Pediatrics, University of Colorado Anschutz School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Badawy+M%22">Badawy M</searchLink>; Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas.<br /><searchLink fieldCode="AU" term="%22Baumer-Mouradian+S%22">Baumer-Mouradian S</searchLink>; Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee.<br /><searchLink fieldCode="AU" term="%22Berthelot+S%22">Berthelot S</searchLink>; Département de Médecine de Famille et de Médecine d'Urgence, Faculté de Médecine, Université Laval et Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec-Université Laval, Quebec, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Clukies+LD%22">Clukies LD</searchLink>; Division of Emergency Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis.<br /><searchLink fieldCode="AU" term="%22Craig+S%22">Craig S</searchLink>; Paediatric Emergency Department, Monash Medical Centre, Melbourne, VIC, Australia.; Department of Pediatrics, Sub-Faculty of Clinical and Molecular Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Curtis+SJ%22">Curtis SJ</searchLink>; Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alberta Stollery Children's Hospital, Edmonton, Canada.; Women and Children's Health Research Institute, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+AL%22">Davis AL</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and the Department of Paediatrics, University of Toronto, Toronto.<br /><searchLink fieldCode="AU" term="%22Duffy+S%22">Duffy S</searchLink>; Hasbro Children's Hospital, Brown University Health, Providence, RI.<br /><searchLink fieldCode="AU" term="%22Eisenberg+MA%22">Eisenberg MA</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, Boston.; Departments of Pediatrics and Emergency Medicine, Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Emsley+JG%22">Emsley JG</searchLink>; IWK Health Centre and Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Faculty of Medicine, Dalhousie University, Halifax NS, Canada.<br /><searchLink fieldCode="AU" term="%22Festekjian+A%22">Festekjian A</searchLink>; Division of Emergency and Transport Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles.; Keck School of Medicine, University of Southern California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Department of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, QLD, Australia.; School of Medicine and Dentistry, Griffith University, Southport, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Green+R%22">Green R</searchLink>; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Gripp+KE%22">Gripp KE</searchLink>; Section of Pediatric Emergency Medicine, Department of Pediatrics and Child Health, Health Sciences Center Winnipeg Children's Hospital, Winnipeg, MB, Canada.; Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Jain+PG%22">Jain PG</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago.<br /><searchLink fieldCode="AU" term="%22Jani+S%22">Jani S</searchLink>; Department of Emergency Medicine, Children's Hospital at Westmead, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Joubert+GI%22">Joubert GI</searchLink>; London Health Sciences Centre and Division of Emergency Medicine, Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.<br /><searchLink fieldCode="AU" term="%22Judge+P%22">Judge P</searchLink>; British Columbia Children's Hospital, Department of Pediatrics, Division of Pediatric Emergency Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Kam+A%22">Kam A</searchLink>; McMaster Children's Hospital and Division of Emergency Medicine, Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kochar+A%22">Kochar A</searchLink>; Department of Emergency Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.; Department of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Koutroulis+I%22">Koutroulis I</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Kwok+MY%22">Kwok MY</searchLink>; Department of Emergency Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Lane+RD%22">Lane RD</searchLink>; Division of Pediatric Emergency Medicine, Primary Children's Hospital, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City.<br /><searchLink fieldCode="AU" term="%22Lithgow+A%22">Lithgow A</searchLink>; Department of Paediatrics, Royal Darwin Hospital, Tiwi, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Lloyd+J%22">Lloyd J</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus.<br /><searchLink fieldCode="AU" term="%22Mansour+K%22">Mansour K</searchLink>; Division of Pediatric Emergency Medicine, Department of Emergency Medicine, University of California San Francisco Benioff Children's Hospitals, Oakland.<br /><searchLink fieldCode="AU" term="%22McManemy+JK%22">McManemy JK</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Texas Children's Hospital and the Department of Pediatrics, Baylor College of Medicine, Houston.<br /><searchLink fieldCode="AU" term="%22Morris+C%22">Morris C</searchLink>; Division of Pediatric Emergency Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta.<br /><searchLink fieldCode="AU" term="%22Phillips+N%22">Phillips N</searchLink>; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia.; Child Health Research Centre, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Rao+A%22">Rao A</searchLink>; Department of Emergency Medicine, Sydney Children's Hospital, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Kensington, Australia.<br /><searchLink fieldCode="AU" term="%22Rogers+A%22">Rogers A</searchLink>; Departments of Emergency Medicine and Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor.<br /><searchLink fieldCode="AU" term="%22Sehgal+A%22">Sehgal A</searchLink>; Kingston Health Sciences Centre and Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shayan+Y%22">Shayan Y</searchLink>; Centre Hospitalier Universitaire Sainte Justine et Département de Pédiatrie, Université de Montréal, Montreal.<br /><searchLink fieldCode="AU" term="%22Silverman+J%22">Silverman J</searchLink>; Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Division of Critical Care, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond.<br /><searchLink fieldCode="AU" term="%22Tan+E%22">Tan E</searchLink>; Middlemore Hospital, Auckland, New Zealand.; Department of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Uspal+NG%22">Uspal NG</searchLink>; University of Washington, Pediatric Emergency Medicine, Seattle Children's Hospital, Seattle.<br /><searchLink fieldCode="AU" term="%22Vance+C%22">Vance C</searchLink>; University of California at Davis Children's Hospital and School of Medicine, Sacramento.<br /><searchLink fieldCode="AU" term="%22Whyte+E%22">Whyte E</searchLink>; Emergency Department, Townsville University Hospital, Douglas, QLD, Australia.; College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Freedman+SB%22">Freedman SB</searchLink>; Sections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics and Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Babl+FE%22">Babl FE</searchLink>; Emergency Department, Royal Children's Hospital, Parkville, VIC, Australia.; Departments of Paediatrics and Critical Care, University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kuppermann+N%22">Kuppermann N</searchLink>; Division of Emergency Medicine, Department of Pediatrics, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC.
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      – TitleFull: Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock.
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            – D: 24
              M: 04
              Text: 2026 Apr 24
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1533-4406
          Titles:
            – TitleFull: The New England journal of medicine
              Type: main
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