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Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.

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Title: Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.
Authors: Furman S; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Zayou L; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Tsourmas KI; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Javonillo DI; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Olivarria GM; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Cheng Y; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA., Pachow C; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA., Fernandez K; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA., Le L; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Edwards RA; Department of Pathology & Laboratory Medicine, School of Medicine, University of California, Irvine, California, USA., Nicholas DA; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA., Sanchez GP; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA., Baric RS; Department of Epidemiology and Department of Microbiology &Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Green KN; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Lane TE; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, California, USA.; Center for Virus Research, University of California, Irvine, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71394.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.
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