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Dynamics of nasal transcriptomics during step-up treatment in children with uncontrolled asthma.

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Title: Dynamics of nasal transcriptomics during step-up treatment in children with uncontrolled asthma.
Authors: Sun Y; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Slob EMA; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands; Department of Clinical Pharmacy, Diakonessenhuis, Utrecht, The Netherlands., Noij LCE; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Karp T; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Gosliga D; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Abdel-Aziz MI; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Vonk JM; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Khalenkow D; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Vijverberg SJH; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Pijnenburg MW; Department of Pediatrics/Respiratory Medicine and Allergology, Erasmus University Medical Center, Rotterdam, The Netherlands., Maitland-van der Zee AH; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Koppelman GH; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Kersten ETG; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: e.t.g.kersten@umcg.nl.
Corporate Authors: PUFFIN Investigators
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2026 Jul; Vol. 158 (1), pp. 322-324. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Letter
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Dynamics of nasal transcriptomics during step-up treatment in children with uncontrolled asthma.
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  Data: <searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Slob+EMA%22">Slob EMA</searchLink>; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands; Department of Clinical Pharmacy, Diakonessenhuis, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Noij+LCE%22">Noij LCE</searchLink>; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Karp+T%22">Karp T</searchLink>; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gosliga+D%22">van Gosliga D</searchLink>; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+MI%22">Abdel-Aziz MI</searchLink>; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vonk+JM%22">Vonk JM</searchLink>; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Khalenkow+D%22">Khalenkow D</searchLink>; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vijverberg+SJH%22">Vijverberg SJH</searchLink>; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+MW%22">Pijnenburg MW</searchLink>; Department of Pediatrics/Respiratory Medicine and Allergology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maitland-van+der+Zee+AH%22">Maitland-van der Zee AH</searchLink>; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koppelman+GH%22">Koppelman GH</searchLink>; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kersten+ETG%22">Kersten ETG</searchLink>; Department of Pediatric Pulmonology & Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: e.t.g.kersten@umcg.nl.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1275002 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6825 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200916749%22">00916749 </searchLink><i>NLM ISO Abbreviation: </i>J Allergy Clin Immunol <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1016/j.jaci.2026.03.015
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