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Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.

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Title: Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.
Authors: Abu-Saleh D; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Koshre GR; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Piper B; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Wang C; Division of Bioinformatics & Computational Biology, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States.; Pelotonia Institute for Immuno-Oncology, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States., Peirce C; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Johnson BS; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Farkas D; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Nho RS; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Horowitz JC; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Ma Q; Division of Bioinformatics & Computational Biology, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States.; Pelotonia Institute for Immuno-Oncology, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States., Mallampalli RK; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States., Goncharova EA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States., Farkas L; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.; Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, United States.
Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2026 Jun 01; Vol. 330 (6), pp. L713-L723. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.
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        Value: 10.1152/ajplung.00299.2025
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