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Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.

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Title: Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.
Authors: Wang Y; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang W; Department of Emergency Medicine, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000, China., Sun J; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Zhou S; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Ni L; Department of Nephrology, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Dong M; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang X; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Yuan Y; Department of Intensive Care Unit, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, 314033, China., Wang J; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Ren P; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Fang W; Department of Animal Experiment Center, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Jin K; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China. Electronic address: kuijin@ustc.edu.cn.
Source: Chemico-biological interactions [Chem Biol Interact] 2026 Jul 01; Vol. 434, pp. 112089. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Emergency Medicine, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Ni+L%22">Ni L</searchLink>; Department of Nephrology, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Dong+M%22">Dong M</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Department of Intensive Care Unit, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, 314033, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China.<br /><searchLink fieldCode="AU" term="%22Ren+P%22">Ren P</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China.<br /><searchLink fieldCode="AU" term="%22Fang+W%22">Fang W</searchLink>; Department of Animal Experiment Center, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China. Electronic address: kuijin@ustc.edu.cn.
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              Text: 2026 Jul 01
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