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Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.

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Title: Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.
Authors: Chalitsios CV; Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece. Electronic address: christos.chalitsios@uoi.gr., Chan WC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Markozannes G; Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Aglago EK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Australia., Campbell PT; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States., Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, United States; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States., Dimou N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France., Drew DA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States., French AJ; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States., Gallinger S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Georgeson P; Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Parkville, Australia., Giannakis M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States; Broad Institute of MIT and Harvard, Cambridge, MA, United States., Gruber SB; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Gunter MJ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Urruchúa-Rodríguez MJ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, University of Heidelberg, Heidelberg, Germany., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States; Department of Biostatistics, University of Washington, Seattle, WA, United States., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Hullar MA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Jayasekara H; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia., Moreno V; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Newton CC; Department of Population Science, American Cancer Society, Atlanta, GA, United States., Nowak JA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Obón-Santacana M; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Ogino S; Broad Institute of MIT and Harvard, Cambridge, MA, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Institute of Science Tokyo, Tokyo, Japan., Pellatt AJ; Department of Medicine, University of Utah, Salt Lake City, Utah, USA., Peoples A; Department of Population Science, American Cancer Society, Atlanta, GA, United States., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Schmit SL; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, United States., Steinfelder RS; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Sun W; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Thomas CE; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Toland AE; Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States., Trinh QM; Ontario Institute for Cancer Research, Toronto, ON, Canada., Ugai T; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States., Um CY; Department of Population Science, American Cancer Society, Atlanta, GA, United States., Van Guelpen B; Department of Diagnostics and Intervention, Oncology Unit, Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Zaidi SH; Ontario Institute for Cancer Research, Toronto, ON, Canada., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, United States., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, United States., Tsilidis KK; Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Source: The American journal of clinical nutrition [Am J Clin Nutr] 2026 Jun; Vol. 123 (6), pp. 101308. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3207 (Electronic) Linking ISSN: 00029165 NLM ISO Abbreviation: Am J Clin Nutr Subsets: MEDLINE
Database: MEDLINE Ultimate
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Electronic address: christos.chalitsios@uoi.gr.<br /><searchLink fieldCode="AU" term="%22Chan+WC%22">Chan WC</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Markozannes+G%22">Markozannes G</searchLink>; Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aglago+EK%22">Aglago EK</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Berndt+SI%22">Berndt SI</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Buchanan+DD%22">Buchanan DD</searchLink>; Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, The University of Melbourne, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Campbell+PT%22">Campbell PT</searchLink>; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, United States; Alvin J. 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              Value: 1938-3207
          Numbering:
            – Type: volume
              Value: 123
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: The American journal of clinical nutrition
              Type: main
ResultId 1