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GFAP degradation in TBI: linking novel modified products to astrocyte pathology and patient outcome.

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Title: GFAP degradation in TBI: linking novel modified products to astrocyte pathology and patient outcome.
Authors: Wanner IB; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA. IWanner@mednet.ucla.edu., Halford J; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA., Lopez J; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA., Shen S; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Chen Y; Molecular Instrumentation Center (MIC), Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., Zhao H; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA., Salas C; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA., Loo RO; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Robicsek S; Department of Anesthesiology, Neurosurgery and Neuroscience, University of Florida, Gainesville, FL, 32610-0254, USA., Ellingson BM; Department of Radiological Sciences, Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Gornbein J; Department of Computational Medicine, Statistics Core of the Department of Medicine, School of Public Health, UCLA, Los Angeles, CA, USA., Van Meter TE; BRAINBox Solutions, Inc., Richmond, VA, 23219, USA., Shaw G; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, 32610, USA.; EnCor Biotechnology Inc., Gainesville, FL, 32608, USA., Loo JA; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Vespa PM; Department Neurology and Neurosurgery, BIRC, David Geffen School of Medicine, Ronald Reagan Medical Center, UCLA, Los Angeles, CA, USA.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Apr 24; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GFAP degradation in TBI: linking novel modified products to astrocyte pathology and patient outcome.
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  Data: <searchLink fieldCode="AU" term="%22Wanner+IB%22">Wanner IB</searchLink>; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA. IWanner@mednet.ucla.edu.<br /><searchLink fieldCode="AU" term="%22Halford+J%22">Halford J</searchLink>; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+J%22">Lopez J</searchLink>; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Molecular Instrumentation Center (MIC), Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Salas+C%22">Salas C</searchLink>; Semel Institute for Neuroscience and Human Behavior, Intellectual and Developmental Disability Center (IDDRC), Brain Injury Research Center (BIRC), David Geffen School of Medicine, UCLA, 635 Charles E. Young Drive South, NRB315, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Loo+RO%22">Loo RO</searchLink>; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Robicsek+S%22">Robicsek S</searchLink>; Department of Anesthesiology, Neurosurgery and Neuroscience, University of Florida, Gainesville, FL, 32610-0254, USA.<br /><searchLink fieldCode="AU" term="%22Ellingson+BM%22">Ellingson BM</searchLink>; Department of Radiological Sciences, Geffen School of Medicine, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gornbein+J%22">Gornbein J</searchLink>; Department of Computational Medicine, Statistics Core of the Department of Medicine, School of Public Health, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Van+Meter+TE%22">Van Meter TE</searchLink>; BRAINBox Solutions, Inc., Richmond, VA, 23219, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+G%22">Shaw G</searchLink>; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, 32610, USA.; EnCor Biotechnology Inc., Gainesville, FL, 32608, USA.<br /><searchLink fieldCode="AU" term="%22Loo+JA%22">Loo JA</searchLink>; Department of Chemistry and Biochemistry, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vespa+PM%22">Vespa PM</searchLink>; Department Neurology and Neurosurgery, BIRC, David Geffen School of Medicine, Ronald Reagan Medical Center, UCLA, Los Angeles, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Apr 24; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s40478-026-02240-y
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        Text: English
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              Text: 2026 Apr 24
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