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Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.

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Title: Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.
Authors: Boscheck H; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany., Luft M; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany. maxie.luft@dzne.de., Mauer R; Faculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, Dresden, Germany., Senguel S; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany., D'elia Y; Center for the Neuroscience of Embodied Cognition (CeNEC) at the Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA., Dechent P; Department of Cognitive Neurology, MR-Research in Neurosciences, University Medical Center Göttingen, Göttingen, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Hetzer S; Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Kronmüller M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Lüsebrink F; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany., Preis L; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Rauchmann B; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.; Department of Neuroradiology, University Hospital LMU, Munich, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Schott BH; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry and Psychotherapy, Otto-Von-Guericke University, Magdeburg, Germany., Sodenkamp S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Spruth E; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Stoecklein S; Department of Radiology, Ludwig Maximilian University Hospital, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Yakupov R; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany., Ziegler G; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Buerger K; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Hellmann-Regen J; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Section for Dementia Research, University of Tübingen, Tübingen, Germany., Perneczky R; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Peters O; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.; Cologne Excellence Cluster On Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Psychiatry and Psychotherapy, Division of Neurogenetics and Molecular Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Parkinson's, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany., Röske S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Glöckner F; Faculty of Psychology, Chair of Lifespan Developmental Neuroscience, TU Dresden, Dresden, Germany., Marchant NL; Division of Psychiatry, University College London, London, UK., Klimecki O; Biological Psychology, University of Innsbruck, Innsbruck, Austria., Wirth M; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany. miranka.wirth@dzne.de.
Corporate Authors: DELCODE study group
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Apr 24; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.
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  Data: <searchLink fieldCode="AU" term="%22Boscheck+H%22">Boscheck H</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Luft+M%22">Luft M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany. maxie.luft@dzne.de.<br /><searchLink fieldCode="AU" term="%22Mauer+R%22">Mauer R</searchLink>; Faculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Senguel+S%22">Senguel S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22D'elia+Y%22">D'elia Y</searchLink>; Center for the Neuroscience of Embodied Cognition (CeNEC) at the Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dechent+P%22">Dechent P</searchLink>; Department of Cognitive Neurology, MR-Research in Neurosciences, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Fliessbach+K%22">Fliessbach K</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Glanz+W%22">Glanz W</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hetzer+S%22">Hetzer S</searchLink>; Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Janowitz+D%22">Janowitz D</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kilimann+I%22">Kilimann I</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Kleineidam+L%22">Kleineidam L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kronmüller+M%22">Kronmüller M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Lüsebrink+F%22">Lüsebrink F</searchLink>; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Preis+L%22">Preis L</searchLink>; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rauchmann+B%22">Rauchmann B</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.; Department of Neuroradiology, University Hospital LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rostamzadeh+A%22">Rostamzadeh A</searchLink>; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schott+BH%22">Schott BH</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry and Psychotherapy, Otto-Von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sodenkamp+S%22">Sodenkamp S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Spruth+E%22">Spruth E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stoecklein+S%22">Stoecklein S</searchLink>; Department of Radiology, Ludwig Maximilian University Hospital, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Yakupov+R%22">Yakupov R</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ziegler+G%22">Ziegler G</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brosseron+F%22">Brosseron F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Buerger+K%22">Buerger K</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hellmann-Regen+J%22">Hellmann-Regen J</searchLink>; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Laske+C%22">Laske C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Section for Dementia Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Perneczky+R%22">Perneczky R</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Priller+J%22">Priller J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.; Cologne Excellence Cluster On Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Psychiatry and Psychotherapy, Division of Neurogenetics and Molecular Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Spottke+A%22">Spottke A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Parkinson's, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Teipel+S%22">Teipel S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Jessen+F%22">Jessen F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Düzel+E%22">Düzel E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Röske+S%22">Röske S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Glöckner+F%22">Glöckner F</searchLink>; Faculty of Psychology, Chair of Lifespan Developmental Neuroscience, TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Marchant+NL%22">Marchant NL</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Klimecki+O%22">Klimecki O</searchLink>; Biological Psychology, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wirth+M%22">Wirth M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307, Germany. miranka.wirth@dzne.de.
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              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1758-9193
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Alzheimer's research & therapy
              Type: main
ResultId 1