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A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics, and pharmacodynamics of OSE-279, an anti-PD-1 monoclonal antibody in patients with advanced solid tumours.

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Title: A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics, and pharmacodynamics of OSE-279, an anti-PD-1 monoclonal antibody in patients with advanced solid tumours.
Authors: Robert M; Institut de Cancérologie de l'Ouest, Saint-Herblain, ARPEGO Network, France., Kotecki N; Institut Jules Bordet, Brussels, Belgium., Gomez-Roca C; IUCT-Oncopole Claudius Régaud, Toulouse, France., Massard C; Centre Eugène Marquis, Rennes, France., Postel-Vinay S; Institut Gustave Roussy, Villejuif, France., Raimbourg J; Institut de Cancérologie de l'Ouest, Saint-Herblain, ARPEGO Network, France., Brandao M; Institut Jules Bordet, Brussels, Belgium., Korakis I; IUCT-Oncopole Claudius Régaud, Toulouse, France., Rouge TM; Centre Eugène Marquis, Rennes, France., Comis S; OSE Immunotherapeutics, Nantes, France., Imadalou K; OSE Immunotherapeutics, Nantes, France., Chevalier C; OSE Immunotherapeutics, Nantes, France., Cordonnier L; OSE Immunotherapeutics, Nantes, France., Josse C; Exystat, Malakoff, France., Teppaz G; OSE Immunotherapeutics, Nantes, France., Seité M; OSE Immunotherapeutics, Nantes, France., Durand J; OSE Immunotherapeutics, Nantes, France., Thepenier V; OSE Immunotherapeutics, Nantes, France., Mary C; OSE Immunotherapeutics, Nantes, France., Gauttier V; OSE Immunotherapeutics, Nantes, France., Derame M; OSE Immunotherapeutics, Nantes, France., Morello A; OSE Immunotherapeutics, Nantes, France., Poirier N; OSE Immunotherapeutics, Nantes, France., Cassier PA; Centre Léon Bérard, Lyon, France. Electronic address: philippe.cassier@lyon.unicancer.fr.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 03; Vol. 240, pp. 116729. Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics, and pharmacodynamics of OSE-279, an anti-PD-1 monoclonal antibody in patients with advanced solid tumours.
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  Data: <searchLink fieldCode="AU" term="%22Robert+M%22">Robert M</searchLink>; Institut de Cancérologie de l'Ouest, Saint-Herblain, ARPEGO Network, France.<br /><searchLink fieldCode="AU" term="%22Kotecki+N%22">Kotecki N</searchLink>; Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Gomez-Roca+C%22">Gomez-Roca C</searchLink>; IUCT-Oncopole Claudius Régaud, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Massard+C%22">Massard C</searchLink>; Centre Eugène Marquis, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Postel-Vinay+S%22">Postel-Vinay S</searchLink>; Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Raimbourg+J%22">Raimbourg J</searchLink>; Institut de Cancérologie de l'Ouest, Saint-Herblain, ARPEGO Network, France.<br /><searchLink fieldCode="AU" term="%22Brandao+M%22">Brandao M</searchLink>; Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Korakis+I%22">Korakis I</searchLink>; IUCT-Oncopole Claudius Régaud, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rouge+TM%22">Rouge TM</searchLink>; Centre Eugène Marquis, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Comis+S%22">Comis S</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Imadalou+K%22">Imadalou K</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Chevalier+C%22">Chevalier C</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Cordonnier+L%22">Cordonnier L</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Josse+C%22">Josse C</searchLink>; Exystat, Malakoff, France.<br /><searchLink fieldCode="AU" term="%22Teppaz+G%22">Teppaz G</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Seité+M%22">Seité M</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Durand+J%22">Durand J</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Thepenier+V%22">Thepenier V</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Mary+C%22">Mary C</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Gauttier+V%22">Gauttier V</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Derame+M%22">Derame M</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Morello+A%22">Morello A</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Poirier+N%22">Poirier N</searchLink>; OSE Immunotherapeutics, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Cassier+PA%22">Cassier PA</searchLink>; Centre Léon Bérard, Lyon, France. Electronic address: philippe.cassier@lyon.unicancer.fr.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 03; Vol. 240, pp. 116729. <i>Date of Electronic Publication: </i>2026 Apr 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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