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Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.

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Title: Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.
Authors: Tosoni G; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Ayyildiz D; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Snoeck S; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Moreno-Jiménez EP; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Penning A; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Santiago-Mujika E; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., Ruiz Ormaechea O; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Lee H; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Poovathingal S; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Microfluidics & Analytics Unit, Leuven, Belgium., Davie K; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Bioinformatics Unit, Leuven, Belgium., Bryois J; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Macnair W; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Anink J; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands., De Vries LE; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Farmand S; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Nutma E; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Swaab DF; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Aronica E; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands., Middeldorp J; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Thuret S; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Roybon L; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., Basak O; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fitzsimons CP; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands., Lucassen PJ; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands., Salta E; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. Electronic address: e.salta@nin.knaw.nl.
Source: Cell stem cell [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 763-783.e9. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
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  Data: Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.
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  Data: <searchLink fieldCode="AU" term="%22Tosoni+G%22">Tosoni G</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ayyildiz+D%22">Ayyildiz D</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Snoeck+S%22">Snoeck S</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moreno-Jiménez+EP%22">Moreno-Jiménez EP</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Penning+A%22">Penning A</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Santiago-Mujika+E%22">Santiago-Mujika E</searchLink>; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+Ormaechea+O%22">Ruiz Ormaechea O</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Poovathingal+S%22">Poovathingal S</searchLink>; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Microfluidics & Analytics Unit, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Davie+K%22">Davie K</searchLink>; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Bioinformatics Unit, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bryois+J%22">Bryois J</searchLink>; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Macnair+W%22">Macnair W</searchLink>; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Anink+J%22">Anink J</searchLink>; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Vries+LE%22">De Vries LE</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Farmand+S%22">Farmand S</searchLink>; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nutma+E%22">Nutma E</searchLink>; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Swaab+DF%22">Swaab DF</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Aronica+E%22">Aronica E</searchLink>; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Middeldorp+J%22">Middeldorp J</searchLink>; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Thuret+S%22">Thuret S</searchLink>; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Roybon+L%22">Roybon L</searchLink>; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Basak+O%22">Basak O</searchLink>; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fitzsimons+CP%22">Fitzsimons CP</searchLink>; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lucassen+PJ%22">Lucassen PJ</searchLink>; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Salta+E%22">Salta E</searchLink>; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. Electronic address: e.salta@nin.knaw.nl.
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  Data: <searchLink fieldCode="JN" term="%22101311472%22">Cell stem cell</searchLink> [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 763-783.e9. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101311472 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1875-9777 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218759777%22">18759777 </searchLink><i>NLM ISO Abbreviation: </i>Cell Stem Cell <i>Subsets: </i>MEDLINE
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