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Etiology, prevalence, and mortality of sepsis among children under five years in Africa: a systematic review and meta-analysis.

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Title: Etiology, prevalence, and mortality of sepsis among children under five years in Africa: a systematic review and meta-analysis.
Authors: Dicko CH; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali., N'Dri DN; Interdisciplinary Laboratory of Biotechnology and Health, Mohammed VI Higher Institute of Biosciences and Biotechnology, Casablanca, 20190, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco., Snoussi M; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco., Nzoyikorera N; National Reference Laboratory, National Public Health Institute, Bujumbura, Burundi., Zouré AA; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso.; Biomedical Research Laboratory (LaReBio), Biomedical and Public Health Department, Health Sciences Research Institute/National Center for Scientific and Technological Research (IRSS/CNRST), Ouagadougou, Burkina Faso., Kambiré D; Biomedical Research Laboratory (LaReBio), Biomedical and Public Health Department, Health Sciences Research Institute/National Center for Scientific and Technological Research (IRSS/CNRST), Ouagadougou, Burkina Faso.; Health Sciences Research Institute (IRSS), National Center for Scientific and Technological Research (CNRST), Ouagadougou, Burkina Faso., Elammari I; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco., Bouziyane A; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco., Halabi MK; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Research Laboratory in Drug Sciences, Mohammed VI Faculty of Pharmacy, Mohammed VI University of Sciences and Health, Casablanca, 82403, Morocco., Bivigou-Mboumba B; Unité Mixte de Recherches CIRMF-SSM (UMR CIRMF-SSM), Hôpital d´Instruction des Armées Omar BONGO ONDIMBA, Libreville, Gabon.; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon., Nayme K; Molecular Bacteriology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco., Iroungou BA; Unité Mixte de Recherches CIRMF-SSM (UMR CIRMF-SSM), Hôpital d´Instruction des Armées Omar BONGO ONDIMBA, Libreville, Gabon.; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon., Khalis M; Department of Public Health and Clinical Research, Mohammed VI Center for Research and Innovation (CM6RI), Rabat, 10112, Morocco.; Mohammed VI International School of Public Health, Mohammed VI University of Sciences and Health, Casablanca, 82403, Morocco.; Higher Institute of Nursing Professions and Health Techniques, Ministry of Health and Social Protection, Rabat, Morocco., Kettani AE; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.; Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, 20250, Morocco., Sylla M; Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.; Department of Pediatrics, Gabriel Touré University Hospital, Bamako, Mali., Founou LL; Reproductive, Maternal, Newborn, and Child Health (ReMARCH) Research Unit, Research Institute of the Centre of Expertise and Biological Diagnostic of Cameroon (CEDBCAM-RI), Yaoundé, Cameroon.; Antimicrobial Research Unit, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.; Infection and Global Health Division, School of Medicine, University of St Andrews, St Andrews, UK., Naitlho A; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco.; Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Mohammed VI Faculty of Medicine, Mohammed VI University of Health and Sciences, Casablanca, Morocco., Aissaoui O; Anesthesia and Critical Care, Ibn Rochd University Hospital, Hassan II University of Casablanca, Casablanca, Morocco., Bakkouri JE; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.; Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Mohammed VI Faculty of Medicine, Mohammed VI University of Health and Sciences, Casablanca, Morocco.; Immunology Laboratory, University Hospital Center Ibn Rochd, Casablanca, Morocco., Jafri A; Interdisciplinary Laboratory of Biotechnology and Health, Mohammed VI Higher Institute of Biosciences and Biotechnology, Casablanca, 20190, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco., Kontao F; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco., Dickson AE; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Elmdaghri N; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco., Chakib A; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco., Bousfiha A; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.; Department of Pediatric Infectious Diseases and Clinical Immunology, Ibn Rushd University Hospital, Casablanca, Morocco., Bouskraoui M; Pediatric Department, Faculty of Medicine and Pharmacy of Marrakech, University Hospital Mohammed VI, Cadi Ayyad University, Marrakech, 40030, Morocco., Adnaoui M; Internal Medicine Department, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco., Dini N; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco., Guindo I; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali. guindo50@gmail.com.; Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. guindo50@gmail.com., Diawara I; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Center for Research and Innovation (CM6RI), Rabat, 10112, Morocco.
Source: BMC infectious diseases [BMC Infect Dis] 2026 Apr 25; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Etiology, prevalence, and mortality of sepsis among children under five years in Africa: a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Dicko+CH%22">Dicko CH</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali.<br /><searchLink fieldCode="AU" term="%22N'Dri+DN%22">N'Dri DN</searchLink>; Interdisciplinary Laboratory of Biotechnology and Health, Mohammed VI Higher Institute of Biosciences and Biotechnology, Casablanca, 20190, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.<br /><searchLink fieldCode="AU" term="%22Snoussi+M%22">Snoussi M</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.<br /><searchLink fieldCode="AU" term="%22Nzoyikorera+N%22">Nzoyikorera N</searchLink>; National Reference Laboratory, National Public Health Institute, Bujumbura, Burundi.<br /><searchLink fieldCode="AU" term="%22Zouré+AA%22">Zouré AA</searchLink>; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso.; Biomedical Research Laboratory (LaReBio), Biomedical and Public Health Department, Health Sciences Research Institute/National Center for Scientific and Technological Research (IRSS/CNRST), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Kambiré+D%22">Kambiré D</searchLink>; Biomedical Research Laboratory (LaReBio), Biomedical and Public Health Department, Health Sciences Research Institute/National Center for Scientific and Technological Research (IRSS/CNRST), Ouagadougou, Burkina Faso.; Health Sciences Research Institute (IRSS), National Center for Scientific and Technological Research (CNRST), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Elammari+I%22">Elammari I</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco.<br /><searchLink fieldCode="AU" term="%22Bouziyane+A%22">Bouziyane A</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco.<br /><searchLink fieldCode="AU" term="%22Halabi+MK%22">Halabi MK</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Research Laboratory in Drug Sciences, Mohammed VI Faculty of Pharmacy, Mohammed VI University of Sciences and Health, Casablanca, 82403, Morocco.<br /><searchLink fieldCode="AU" term="%22Bivigou-Mboumba+B%22">Bivigou-Mboumba B</searchLink>; Unité Mixte de Recherches CIRMF-SSM (UMR CIRMF-SSM), Hôpital d´Instruction des Armées Omar BONGO ONDIMBA, Libreville, Gabon.; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.<br /><searchLink fieldCode="AU" term="%22Nayme+K%22">Nayme K</searchLink>; Molecular Bacteriology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Iroungou+BA%22">Iroungou BA</searchLink>; Unité Mixte de Recherches CIRMF-SSM (UMR CIRMF-SSM), Hôpital d´Instruction des Armées Omar BONGO ONDIMBA, Libreville, Gabon.; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.<br /><searchLink fieldCode="AU" term="%22Khalis+M%22">Khalis M</searchLink>; Department of Public Health and Clinical Research, Mohammed VI Center for Research and Innovation (CM6RI), Rabat, 10112, Morocco.; Mohammed VI International School of Public Health, Mohammed VI University of Sciences and Health, Casablanca, 82403, Morocco.; Higher Institute of Nursing Professions and Health Techniques, Ministry of Health and Social Protection, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Kettani+AE%22">Kettani AE</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.; Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, 20250, Morocco.<br /><searchLink fieldCode="AU" term="%22Sylla+M%22">Sylla M</searchLink>; Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.; Department of Pediatrics, Gabriel Touré University Hospital, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Founou+LL%22">Founou LL</searchLink>; Reproductive, Maternal, Newborn, and Child Health (ReMARCH) Research Unit, Research Institute of the Centre of Expertise and Biological Diagnostic of Cameroon (CEDBCAM-RI), Yaoundé, Cameroon.; Antimicrobial Research Unit, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.; Infection and Global Health Division, School of Medicine, University of St Andrews, St Andrews, UK.<br /><searchLink fieldCode="AU" term="%22Naitlho+A%22">Naitlho A</searchLink>; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; 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Interdisciplinary Laboratory of Biotechnology and Health, Mohammed VI Higher Institute of Biosciences and Biotechnology, Casablanca, 20190, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.<br /><searchLink fieldCode="AU" term="%22Kontao+F%22">Kontao F</searchLink>; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.<br /><searchLink fieldCode="AU" term="%22Dickson+AE%22">Dickson AE</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Elmdaghri+N%22">Elmdaghri N</searchLink>; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.<br /><searchLink fieldCode="AU" term="%22Chakib+A%22">Chakib A</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco.<br /><searchLink fieldCode="AU" term="%22Bousfiha+A%22">Bousfiha A</searchLink>; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, 20250, Morocco.; Department of Pediatric Infectious Diseases and Clinical Immunology, Ibn Rushd University Hospital, Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Bouskraoui+M%22">Bouskraoui M</searchLink>; Pediatric Department, Faculty of Medicine and Pharmacy of Marrakech, University Hospital Mohammed VI, Cadi Ayyad University, Marrakech, 40030, Morocco.<br /><searchLink fieldCode="AU" term="%22Adnaoui+M%22">Adnaoui M</searchLink>; Internal Medicine Department, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Dini+N%22">Dini N</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 20180, Morocco.; Cheikh Khalifa International University Hospital, Casablanca, 82403, Morocco.; Mohammed VI International University Hospital, Bouskoura, 27182, Morocco.<br /><searchLink fieldCode="AU" term="%22Guindo+I%22">Guindo I</searchLink>; National Public Health Institute, Hippodrome, Koulikoro Road - Street 235, Gate 52 - Commune II, Bamako, BP1771, Mali. guindo50@gmail.com.; Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. guindo50@gmail.com.<br /><searchLink fieldCode="AU" term="%22Diawara+I%22">Diawara I</searchLink>; Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Higher Institute of Biosciences and Biotechnologies, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, 82403, Morocco.; Mohammed VI Center for Research and Innovation (CM6RI), Rabat, 10112, Morocco.
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          Numbering:
            – Type: volume
              Value: 26
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: BMC infectious diseases
              Type: main
ResultId 1