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Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.

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Title: Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.
Authors: Cohen CE; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Wellcome Sanger Institute, Cambridge, UK., Fernandez S; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Yaman U; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK., Ehyaei AR; Max-Planck-Institute for Intelligent Systems, Tubingen, Germany., Kodosaki E; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK., Askarova A; UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Porter T; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., O'Brien E; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Maruff P; Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.; CogState Ltd, Melbourne, Australia., Nott A; UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Hardy JA; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK.; Reta Lila Weston Institute of Neurological Studies, London, UK., Laws SM; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., A Salih D; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK., Shoai M; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. m.shoai@ucl.ac.uk.; Dementia Research Institute, University College London, London, UK. m.shoai@ucl.ac.uk.
Corporate Authors: Australian Imaging Biomarkers and Lifestyle Study, Alzheimer’s Disease Neuroimaging Initiative
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Apr 25; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.
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  Data: <searchLink fieldCode="AU" term="%22Cohen+CE%22">Cohen CE</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fernandez+S%22">Fernandez S</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Yaman+U%22">Yaman U</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ehyaei+AR%22">Ehyaei AR</searchLink>; Max-Planck-Institute for Intelligent Systems, Tubingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kodosaki+E%22">Kodosaki E</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Askarova+A%22">Askarova A</searchLink>; UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Porter+T%22">Porter T</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+E%22">O'Brien E</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Maruff+P%22">Maruff P</searchLink>; Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.; CogState Ltd, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Nott+A%22">Nott A</searchLink>; UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hardy+JA%22">Hardy JA</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK.; Reta Lila Weston Institute of Neurological Studies, London, UK.<br /><searchLink fieldCode="AU" term="%22Laws+SM%22">Laws SM</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22A+Salih+D%22">A Salih D</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Dementia Research Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Shoai+M%22">Shoai M</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. m.shoai@ucl.ac.uk.; Dementia Research Institute, University College London, London, UK. m.shoai@ucl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 Apr 25; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Apr 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13195-026-02036-1
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              Text: 2026 Apr 25
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