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Synthesis, characterization, and DFT study of a novel pyrido[2',3':4,5]pyrimido[2,1-b][1,3]thiazines via Michael addition and intramolecular cyclization.

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Title: Synthesis, characterization, and DFT study of a novel pyrido[2',3':4,5]pyrimido[2,1-b][1,3]thiazines via Michael addition and intramolecular cyclization.
Authors: Huwaimel B; Dpartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, 81442, Hail, Saudi Arabia.; Medical and Diagnostic Research Center, University of Ha'il, 55473, Hail, Saudi Arabia., Gomha SM; Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia. smgomha@iu.edu.sa., Ebaid MS; Department of Chemistry, College of Science, Northern Border University, 91431, Arar, Saudi Arabia., Abouzied AS; Dpartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, 81442, Hail, Saudi Arabia., Riyadh SM; Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt., Ahmed MSM; Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt., Zaki MEA; Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia. mezaki@imamu.edu.sa., Al-Hussain SA; Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia., Hussein WM; Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia., El-Reedy AAM; Department of Basic and Applied Science, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, Egypt.
Source: BMC chemistry [BMC Chem] 2026 Apr 25; Vol. 20 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 101741142 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-801X (Electronic) Linking ISSN: 2661801X NLM ISO Abbreviation: BMC Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis, characterization, and DFT study of a novel pyrido[2',3':4,5]pyrimido[2,1-b][1,3]thiazines via Michael addition and intramolecular cyclization.
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  Data: <searchLink fieldCode="AU" term="%22Huwaimel+B%22">Huwaimel B</searchLink>; Dpartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, 81442, Hail, Saudi Arabia.; Medical and Diagnostic Research Center, University of Ha'il, 55473, Hail, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Gomha+SM%22">Gomha SM</searchLink>; Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia. smgomha@iu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Ebaid+MS%22">Ebaid MS</searchLink>; Department of Chemistry, College of Science, Northern Border University, 91431, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abouzied+AS%22">Abouzied AS</searchLink>; Dpartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, 81442, Hail, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Riyadh+SM%22">Riyadh SM</searchLink>; Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+MSM%22">Ahmed MSM</searchLink>; Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt.<br /><searchLink fieldCode="AU" term="%22Zaki+MEA%22">Zaki MEA</searchLink>; Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia. mezaki@imamu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Al-Hussain+SA%22">Al-Hussain SA</searchLink>; Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Hussein+WM%22">Hussein WM</searchLink>; Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El-Reedy+AAM%22">El-Reedy AAM</searchLink>; Department of Basic and Applied Science, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101741142%22">BMC chemistry</searchLink> [BMC Chem] 2026 Apr 25; Vol. 20 (1). <i>Date of Electronic Publication: </i>2026 Apr 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101741142 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2661-801X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222661801X%22">2661801X </searchLink><i>NLM ISO Abbreviation: </i>BMC Chem <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Apr 25
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