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Data-driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology.

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Title: Data-driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology.
Authors: Shahidehpour RK; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA., Neltner AM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Klusty MA; Institute for Biomedical Informatics, University of Kentucky, Lexington, Kentucky, USA., Corbett C; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Gonzalez AD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Gutman DA; Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA., Fardo DW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Bachstetter AD; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA., Bumgardner C; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA., Flanagan ME; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Nelson PT; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.
Source: Brain pathology (Zurich, Switzerland) [Brain Pathol] 2026 Apr 26, pp. e70102. Date of Electronic Publication: 2026 Apr 26.
Publication Type: Journal Article
Journal Info: Publisher: International Society of Neuropathology Country of Publication: Switzerland NLM ID: 9216781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3639 (Electronic) Linking ISSN: 10156305 NLM ISO Abbreviation: Brain Pathol Subsets: MEDLINE
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  Data: Data-driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology.
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  Data: <searchLink fieldCode="AU" term="%22Shahidehpour+RK%22">Shahidehpour RK</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Neltner+AM%22">Neltner AM</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Klusty+MA%22">Klusty MA</searchLink>; Institute for Biomedical Informatics, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Corbett+C%22">Corbett C</searchLink>; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+AD%22">Gonzalez AD</searchLink>; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gutman+DA%22">Gutman DA</searchLink>; Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Fardo+DW%22">Fardo DW</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Bachstetter+AD%22">Bachstetter AD</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Bumgardner+C%22">Bumgardner C</searchLink>; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Flanagan+ME%22">Flanagan ME</searchLink>; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+PT%22">Nelson PT</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.
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  Data: <searchLink fieldCode="JN" term="%229216781%22">Brain pathology (Zurich, Switzerland)</searchLink> [Brain Pathol] 2026 Apr 26, pp. e70102. <i>Date of Electronic Publication: </i>2026 Apr 26.
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