Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial.
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| Title: | Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial. |
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| Authors: | Steinhardt LC; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: LSteinhardt@cdc.gov., Kwambai TK; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Kisumu, Kenya., Oneko M; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Ouma E; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Njoroge R; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Callier V; Clinical Monitoring Research Program Directorate, Frederick National Laboratory, Frederick, MD, USA., Hu Z; Office of Biostatistics Research, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Gutman JR; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Yego R; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Otieno K; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Onoka K; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Otieno L; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Oduol K; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Serebryannyy L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Adams W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Hickman S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Preston AC; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Carlton K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Holdsworth M; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Xiao Y; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., O Ter Kuile F; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Odongo W; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Murphy SC; Malaria Molecular Diagnostic Laboratory, Department of Laboratory Medicine and Pathology, and the Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA., Tran TM; Division of Infectious Diseases, Department of Medicine and Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Kariuki S; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya., Crompton PD; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. Electronic address: pcrompton@niaid.nih.gov., Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. |
| Corporate Authors: | Kenya Malaria mAb Trials Team |
| Source: | Lancet (London, England) [Lancet] 2026 Apr 25; Vol. 407 (10539), pp. 1614-1625. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42035777 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Steinhardt+LC%22">Steinhardt LC</searchLink>; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: LSteinhardt@cdc.gov.<br /><searchLink fieldCode="AU" term="%22Kwambai+TK%22">Kwambai TK</searchLink>; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Oneko+M%22">Oneko M</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Ouma+E%22">Ouma E</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Njoroge+R%22">Njoroge R</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Callier+V%22">Callier V</searchLink>; Clinical Monitoring Research Program Directorate, Frederick National Laboratory, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Office of Biostatistics Research, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gutman+JR%22">Gutman JR</searchLink>; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Yego+R%22">Yego R</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+K%22">Otieno K</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Onoka+K%22">Onoka K</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+L%22">Otieno L</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Oduol+K%22">Oduol K</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Serebryannyy+L%22">Serebryannyy L</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Adams+W%22">Adams W</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hickman+S%22">Hickman S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Preston+AC%22">Preston AC</searchLink>; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Carlton+K%22">Carlton K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Holdsworth+M%22">Holdsworth M</searchLink>; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22O+Ter+Kuile+F%22">O Ter Kuile F</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Odongo+W%22">Odongo W</searchLink>; Malaria Branch, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+SC%22">Murphy SC</searchLink>; Malaria Molecular Diagnostic Laboratory, Department of Laboratory Medicine and Pathology, and the Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+TM%22">Tran TM</searchLink>; Division of Infectious Diseases, Department of Medicine and Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Kariuki+S%22">Kariuki S</searchLink>; Kenya Medical Research Institute, Global Health Research Centre, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Crompton+PD%22">Crompton PD</searchLink>; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. Electronic address: pcrompton@niaid.nih.gov.<br /><searchLink fieldCode="AU" term="%22Seder+RA%22">Seder RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Kenya+Malaria+mAb+Trials+Team%22">Kenya Malaria mAb Trials Team</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2026 Apr 25; Vol. 407 (10539), pp. 1614-1625. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42035777 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0140-6736(26)00258-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1614 Titles: – TitleFull: Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Steinhardt LC – PersonEntity: Name: NameFull: Kwambai TK – PersonEntity: Name: NameFull: Oneko M – PersonEntity: Name: NameFull: Ouma E – PersonEntity: Name: NameFull: Njoroge R – PersonEntity: Name: NameFull: Callier V – PersonEntity: Name: NameFull: Hu Z – PersonEntity: Name: NameFull: Gutman JR – PersonEntity: Name: NameFull: Yego R – PersonEntity: Name: NameFull: Otieno K – PersonEntity: Name: NameFull: Onoka K – PersonEntity: Name: NameFull: Otieno L – PersonEntity: Name: NameFull: Oduol K – PersonEntity: Name: NameFull: Serebryannyy L – PersonEntity: Name: NameFull: Lin BC – PersonEntity: Name: NameFull: Adams W – PersonEntity: Name: NameFull: Hickman S – PersonEntity: Name: NameFull: Preston AC – PersonEntity: Name: NameFull: Carlton K – PersonEntity: Name: NameFull: Holdsworth M – PersonEntity: Name: NameFull: Xiao Y – PersonEntity: Name: NameFull: O Ter Kuile F – PersonEntity: Name: NameFull: Odongo W – PersonEntity: Name: NameFull: Murphy SC – PersonEntity: Name: NameFull: Tran TM – PersonEntity: Name: NameFull: Kariuki S – PersonEntity: Name: NameFull: Crompton PD – PersonEntity: Name: NameFull: Seder RA IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 04 Text: 2026 Apr 25 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1474-547X Numbering: – Type: volume Value: 407 – Type: issue Value: 10539 Titles: – TitleFull: Lancet (London, England) Type: main |
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