Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC).
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| Title: | Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC). |
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| Authors: | Lowe DM; Institute of Immunity and Transplantation, University College London, London, UK; Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, UK. Electronic address: d.lowe@ucl.ac.uk., Zhang S; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK., Ellis S; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK., Buggiotti L; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK., Miller C; Great Ormond Street Hospital for Children NHS Trust, London, UK., Harris V; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Shields AM; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Richter AG; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Ashmore E; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Yu LM; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Khoo S; Department of Pharmacology, University of Liverpool, Liverpool, UK; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Hobbs FDR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Little P; Primary Care Research Centre, University of Southampton, Southampton, UK., Butler CC; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Breuer J; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children NHS Trust, London, UK., Standing JF; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK; School of Pharmacy, University College London, London, UK; Great Ormond Street Hospital for Children NHS Trust, London, UK. |
| Corporate Authors: | PANORAMIC Trial Collaborative Group and PANORAMIC Trial Virology Group |
| Source: | The Lancet. Microbe [Lancet Microbe] 2026 May; Vol. 7 (5), pp. 101360. Date of Electronic Publication: 2026 Apr 23. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42035785 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lowe+DM%22">Lowe DM</searchLink>; Institute of Immunity and Transplantation, University College London, London, UK; Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, UK. Electronic address: d.lowe@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ellis+S%22">Ellis S</searchLink>; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Buggiotti+L%22">Buggiotti L</searchLink>; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Miller+C%22">Miller C</searchLink>; Great Ormond Street Hospital for Children NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Harris+V%22">Harris V</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shields+AM%22">Shields AM</searchLink>; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Richter+AG%22">Richter AG</searchLink>; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Ashmore+E%22">Ashmore E</searchLink>; Clinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Yu+LM%22">Yu LM</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Khoo+S%22">Khoo S</searchLink>; Department of Pharmacology, University of Liverpool, Liverpool, UK; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hobbs+FDR%22">Hobbs FDR</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Little+P%22">Little P</searchLink>; Primary Care Research Centre, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Butler+CC%22">Butler CC</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Breuer+J%22">Breuer J</searchLink>; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Standing+JF%22">Standing JF</searchLink>; Infection, Immunity, and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK; School of Pharmacy, University College London, London, UK; Great Ormond Street Hospital for Children NHS Trust, London, UK. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22PANORAMIC+Trial+Collaborative+Group+and+PANORAMIC+Trial+Virology+Group%22">PANORAMIC Trial Collaborative Group and PANORAMIC Trial Virology Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2026 May; Vol. 7 (5), pp. 101360. <i>Date of Electronic Publication: </i>2026 Apr 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101769019 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-5247 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226665247%22">26665247 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Microbe <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42035785 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lanmic.2026.101360 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 101360 Titles: – TitleFull: Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lowe DM – PersonEntity: Name: NameFull: Zhang S – PersonEntity: Name: NameFull: Ellis S – PersonEntity: Name: NameFull: Buggiotti L – PersonEntity: Name: NameFull: Miller C – PersonEntity: Name: NameFull: Harris V – PersonEntity: Name: NameFull: Shields AM – PersonEntity: Name: NameFull: Richter AG – PersonEntity: Name: NameFull: Ashmore E – PersonEntity: Name: NameFull: Yu LM – PersonEntity: Name: NameFull: Khoo S – PersonEntity: Name: NameFull: Hobbs FDR – PersonEntity: Name: NameFull: Little P – PersonEntity: Name: NameFull: Butler CC – PersonEntity: Name: NameFull: Breuer J – PersonEntity: Name: NameFull: Standing JF IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2666-5247 Numbering: – Type: volume Value: 7 – Type: issue Value: 5 Titles: – TitleFull: The Lancet. Microbe Type: main |
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