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Analysis of mitochondrial DNA heteroplasmy in sporadic ALS suggests technical limitations rather than disease association.

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Title: Analysis of mitochondrial DNA heteroplasmy in sporadic ALS suggests technical limitations rather than disease association.
Authors: Codron P; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France. Electronic address: philippe.codron@chu-angers.fr., Desquiret V; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France., Prunier D; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France., Amati-Bonneau P; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France., Nguefackngoune V; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France., Rapenne C; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France., Legoff L; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France., Cassereau J; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France., Procaccio V; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France.
Source: Neurobiology of disease [Neurobiol Dis] 2026 Jun 15; Vol. 224, pp. 107412. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
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  Data: Analysis of mitochondrial DNA heteroplasmy in sporadic ALS suggests technical limitations rather than disease association.
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  Data: <searchLink fieldCode="AU" term="%22Codron+P%22">Codron P</searchLink>; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France. Electronic address: philippe.codron@chu-angers.fr.<br /><searchLink fieldCode="AU" term="%22Desquiret+V%22">Desquiret V</searchLink>; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Prunier+D%22">Prunier D</searchLink>; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Amati-Bonneau+P%22">Amati-Bonneau P</searchLink>; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Nguefackngoune+V%22">Nguefackngoune V</searchLink>; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Rapenne+C%22">Rapenne C</searchLink>; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Legoff+L%22">Legoff L</searchLink>; Biochemistry and Molecular Biology Laboratory, University Hospital of Angers, 49933 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Cassereau+J%22">Cassereau J</searchLink>; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Procaccio+V%22">Procaccio V</searchLink>; ALS Reference Centre, University Hospital of Angers, 49933 Angers, France; Univ Angers, Inserm U1083, CNRS 6015, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France; Department of Genetics, University Hospital of Angers, 49933 Angers, France.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Jun 15; Vol. 224, pp. 107412. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 15
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