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Optimization of an antifungal formulation based on eucalyptol, β-pinene, and α-terpinene against Candida albicans and Candida glabrata: A mixture design study.

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Title: Optimization of an antifungal formulation based on eucalyptol, β-pinene, and α-terpinene against Candida albicans and Candida glabrata: A mixture design study.
Authors: Bougrine S; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco., Elbouzidi A; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco. amine.elbouzidi@ump.ac.ma., Taibi M; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco.; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco., Haddou M; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco., Baraich A; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco., Barraki S; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco., Idrissi Yahyaoui M; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco., Bellaouchi R; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco., Asehraou A; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco., Chaabane K; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco., Addi M; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco., Benabbes R; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco., El Guerrouj B; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul; Vol. 399 (10), pp. 15375-15394. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bougrine+S%22">Bougrine S</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Elbouzidi+A%22">Elbouzidi A</searchLink>; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco. amine.elbouzidi@ump.ac.ma.<br /><searchLink fieldCode="AU" term="%22Taibi+M%22">Taibi M</searchLink>; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco.; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Haddou+M%22">Haddou M</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Baraich+A%22">Baraich A</searchLink>; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Barraki+S%22">Barraki S</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Idrissi+Yahyaoui+M%22">Idrissi Yahyaoui M</searchLink>; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Bellaouchi+R%22">Bellaouchi R</searchLink>; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Asehraou+A%22">Asehraou A</searchLink>; Laboratoire d'Amélioration Des Productions Agricoles, Biotechnologie Et Environnement (LAPABE), Faculté Des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Chaabane+K%22">Chaabane K</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Addi+M%22">Addi M</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Benabbes+R%22">Benabbes R</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22El+Guerrouj+B%22">El Guerrouj B</searchLink>; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda, 60000, Morocco.; Centre de L'Oriental Des Sciences Et Technologies de L'Eau Et de L'Environnement (COSTEE), Université Mohammed Premier, Oujda, 60000, Morocco.
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