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The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study.

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Title: The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study.
Authors: Rodríguez-Sojo MJ; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Hidalgo-García L; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany., Molina-Tijeras JA; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., López-Escanez L; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Gbati L; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Vezza T; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Servicio de Digestivo, Hospital Universitario Virgen de Las Nieves, Granada, Spain., Diez-Echave P; Allergy Research Group, IBIMA Plataforma BIONAND, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain., Ruiz-Malagón AJ; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., García-García J; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Servicio Microbiología, Hospital Universitario Clínico San Cecilio, Granada, Spain., García F; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Servicio Microbiología, Hospital Universitario Clínico San Cecilio, Granada, Spain.; CIBER de Enfermedades Infecciosas (CIBER-Infecc), Instituto de Salud Carlos III, Madrid, Spain., Baños A; DMC Research Center, Granada, Spain., Gil-Martínez L; DMC Research Center, Granada, Spain., López-Posadas R; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.; Department of Medicine 1, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany., Neurath MF; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.; Department of Medicine 1, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany., Gálvez J; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Centro de Investigación Biomédica en Red-Enfermedades Hepáticas y Digestivas (CIBER-EHD), Instituto de Salud Carlos III, Madrid, Spain., Rodríguez-Cabezas ME; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Rodríguez-Nogales A; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.
Source: Phytotherapy research : PTR [Phytother Res] 2026 Jul; Vol. 40 (7), pp. 4124-4146. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rodríguez-Sojo+MJ%22">Rodríguez-Sojo MJ</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Hidalgo-García+L%22">Hidalgo-García L</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Molina-Tijeras+JA%22">Molina-Tijeras JA</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22López-Escanez+L%22">López-Escanez L</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Gbati+L%22">Gbati L</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Vezza+T%22">Vezza T</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Servicio de Digestivo, Hospital Universitario Virgen de Las Nieves, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Diez-Echave+P%22">Diez-Echave P</searchLink>; Allergy Research Group, IBIMA Plataforma BIONAND, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz-Malagón+AJ%22">Ruiz-Malagón AJ</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22García-García+J%22">García-García J</searchLink>; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Servicio Microbiología, Hospital Universitario Clínico San Cecilio, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22García+F%22">García F</searchLink>; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Servicio Microbiología, Hospital Universitario Clínico San Cecilio, Granada, Spain.; CIBER de Enfermedades Infecciosas (CIBER-Infecc), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Baños+A%22">Baños A</searchLink>; DMC Research Center, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Gil-Martínez+L%22">Gil-Martínez L</searchLink>; DMC Research Center, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22López-Posadas+R%22">López-Posadas R</searchLink>; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.; Department of Medicine 1, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany.<br /><searchLink fieldCode="AU" term="%22Neurath+MF%22">Neurath MF</searchLink>; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.; Department of Medicine 1, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany.<br /><searchLink fieldCode="AU" term="%22Gálvez+J%22">Gálvez J</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.; Centro de Investigación Biomédica en Red-Enfermedades Hepáticas y Digestivas (CIBER-EHD), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Cabezas+ME%22">Rodríguez-Cabezas ME</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Nogales+A%22">Rodríguez-Nogales A</searchLink>; Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.
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  Data: <searchLink fieldCode="JN" term="%228904486%22">Phytotherapy research : PTR</searchLink> [Phytother Res] 2026 Jul; Vol. 40 (7), pp. 4124-4146. <i>Date of Electronic Publication: </i>2026 Apr 27.
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