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Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice.

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Title: Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice.
Authors: Novelli EM; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Lenhart SC; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Foley LM; Advanced Imaging Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15203, USA., Sekar N; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Mondal P; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Wang H; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hitchens TK; Advanced Imaging Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15203, USA., Ghosh S; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Chan SY; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hu X; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hazra R; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Source: PNAS nexus [PNAS Nexus] 2026 Apr 08; Vol. 5 (4), pp. pgag106. Date of Electronic Publication: 2026 Apr 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE
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  Data: Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice.
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  Data: <searchLink fieldCode="AU" term="%22Novelli+EM%22">Novelli EM</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Lenhart+SC%22">Lenhart SC</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Foley+LM%22">Foley LM</searchLink>; Advanced Imaging Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15203, USA.<br /><searchLink fieldCode="AU" term="%22Sekar+N%22">Sekar N</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Mondal+P%22">Mondal P</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Hitchens+TK%22">Hitchens TK</searchLink>; Advanced Imaging Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15203, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Chan+SY%22">Chan SY</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Hazra+R%22">Hazra R</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute and Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
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  Data: <searchLink fieldCode="JN" term="%229918367777906676%22">PNAS nexus</searchLink> [PNAS Nexus] 2026 Apr 08; Vol. 5 (4), pp. pgag106. <i>Date of Electronic Publication: </i>2026 Apr 08 (<i>Print Publication: </i>2026).
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              Text: 2026 Apr 08
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