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Non-viral gene therapy for hemophilia A: long-term outcomes of minicircle FVIII delivery in a mouse model.

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Title: Non-viral gene therapy for hemophilia A: long-term outcomes of minicircle FVIII delivery in a mouse model.
Authors: Kao YT; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan., Yen CC; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan., Ro-Lin Chang G; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan., Chiang HT; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan., Chen JK; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan.; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Tainan, Taiwan., Sufian M; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Chen IC; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan., Yang SH; Department of Physiology, Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Chen CM; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan.; The iEGG and Animal Biotechnology Center, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Center for General Educational, National Quemoy University, Kinmen, Taiwan.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 09; Vol. 17, pp. 1742144. Date of Electronic Publication: 2026 Apr 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-viral gene therapy for hemophilia A: long-term outcomes of minicircle FVIII delivery in a mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Kao+YT%22">Kao YT</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+CC%22">Yen CC</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ro-Lin+Chang+G%22">Ro-Lin Chang G</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+HT%22">Chiang HT</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JK%22">Chen JK</searchLink>; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan.; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sufian+M%22">Sufian M</searchLink>; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Chen+IC%22">Chen IC</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SH%22">Yang SH</searchLink>; Department of Physiology, Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CM%22">Chen CM</searchLink>; Department of Life Sciences, and Doctorial Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Health Research Institutes and National Chung Hsing University, Taichung, Taiwan.; The iEGG and Animal Biotechnology Center, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Center for General Educational, National Quemoy University, Kinmen, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Apr 09; Vol. 17, pp. 1742144. <i>Date of Electronic Publication: </i>2026 Apr 09 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42038313
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        Value: 10.3389/fphar.2026.1742144
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            – D: 09
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              Text: 2026 Apr 09
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