Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner's Guide.

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Title: Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner's Guide.
Authors: Chang HC; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Shi Y; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Cheng H; Department of Computational Biology, Carnegie Mellon University School of Computer Science, Pittsburgh, PA, USA., Zou J; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Chang AC; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Schlegel BT; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Wang W; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Brown DD; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Chen F; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Dana Farber Cancer Institute, Boston, MA, USA., Wang S; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Li D; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Sai R; Department of Chemistry, University of Pittsburgh School of Arts and Sciences, Pittsburgh, PA, USA., Michel N; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA., Oesterreich S; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Lee AV; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Tseng GC; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 15. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chang+HC%22">Chang HC</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Department of Computational Biology, Carnegie Mellon University School of Computer Science, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zou+J%22">Zou J</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+AC%22">Chang AC</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schlegel+BT%22">Schlegel BT</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+DD%22">Brown DD</searchLink>; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Dana Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sai+R%22">Sai R</searchLink>; Department of Chemistry, University of Pittsburgh School of Arts and Sciences, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Michel+N%22">Michel N</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Oesterreich+S%22">Oesterreich S</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AV%22">Lee AV</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+GC%22">Tseng GC</searchLink>; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
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