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Natively entangled proteins are linked to human disease and pathogenic mutations likely due to a greater misfolding propensity.

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Title: Natively entangled proteins are linked to human disease and pathogenic mutations likely due to a greater misfolding propensity.
Authors: Anglero Mendez MF; Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA.; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA., Sitarik I; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA., Vu QV; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA., Totoo P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL -EBI) Wellcome Genome Campus, Hinxton, CB10 1SD, UK., Stephenson JD; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL -EBI) Wellcome Genome Campus, Hinxton, CB10 1SD, UK., Song H; Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA., O'Brien EP; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 18. Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Natively entangled proteins are linked to human disease and pathogenic mutations likely due to a greater misfolding propensity.
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  Data: <searchLink fieldCode="AU" term="%22Anglero+Mendez+MF%22">Anglero Mendez MF</searchLink>; Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA.; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sitarik+I%22">Sitarik I</searchLink>; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vu+QV%22">Vu QV</searchLink>; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.<br /><searchLink fieldCode="AU" term="%22Totoo+P%22">Totoo P</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL -EBI) Wellcome Genome Campus, Hinxton, CB10 1SD, UK.<br /><searchLink fieldCode="AU" term="%22Stephenson+JD%22">Stephenson JD</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL -EBI) Wellcome Genome Campus, Hinxton, CB10 1SD, UK.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+EP%22">O'Brien EP</searchLink>; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.; National Synthesis Center for Emergence in the Molecular and Cellular Sciences, Pennsylvania State University, University Park, PA, USA.; Lead contact.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Apr 18. <i>Date of Electronic Publication: </i>2026 Apr 18.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.04.15.718104
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              Text: 2026 Apr 18
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