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High-Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor.

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Title: High-Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor.
Authors: Ji SL; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Chen P; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Tang H; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Zhou C; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Li Z; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Wang Y; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Cao X; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Zhu L; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Bao X; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Liu Z; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Chen Y; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China., Xu Y; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.
Source: MedComm [MedComm (2020)] 2026 Apr 23; Vol. 7, pp. e70695. Date of Electronic Publication: 2026 Apr 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: China NLM ID: 101769925 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-2663 (Electronic) Linking ISSN: 26882663 NLM ISO Abbreviation: MedComm (2020) Subsets: PubMed not MEDLINE
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  Data: High-Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Ji+SL%22">Ji SL</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; 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Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Bao+X%22">Bao X</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Neurology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing China.; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China.; Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing University Nanjing China.; Nanjing Neurology Clinical Medical Center Nanjing China.
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