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Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastoma.

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Title: Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastoma.
Authors: Barnwal A; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Yan W; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Cook SL; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Urup T; Danish Comprehensive Cancer Center, Brain Tumor Center (DCCC-BTC), Blegdamsvej 9, Copenhagen, 2100, Denmark.; Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark., Stevenson K; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., He Y; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Osorio C; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Parker S; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA., Edouard E; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Bowie M; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Jackson HC; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Danish Comprehensive Cancer Center, Brain Tumor Center (DCCC-BTC), Blegdamsvej 9, Copenhagen, 2100, Denmark.; Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA., McLendon RE; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Desjardins A; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Ashley DM; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Bigner DD; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Chandramohan V; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Source: Research square [Res Sq] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Barnwal+A%22">Barnwal A</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yan+W%22">Yan W</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cook+SL%22">Cook SL</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Urup+T%22">Urup T</searchLink>; Danish Comprehensive Cancer Center, Brain Tumor Center (DCCC-BTC), Blegdamsvej 9, Copenhagen, 2100, Denmark.; Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Stevenson+K%22">Stevenson K</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Osorio+C%22">Osorio C</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Parker+S%22">Parker S</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Edouard+E%22">Edouard E</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bowie+M%22">Bowie M</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+HC%22">Jackson HC</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Danish Comprehensive Cancer Center, Brain Tumor Center (DCCC-BTC), Blegdamsvej 9, Copenhagen, 2100, Denmark.; Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McLendon+RE%22">McLendon RE</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Desjardins+A%22">Desjardins A</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ashley+DM%22">Ashley DM</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bigner+DD%22">Bigner DD</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chandramohan+V%22">Chandramohan V</searchLink>; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
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